源自DRw9细胞系的HLA - DQα链的核苷酸序列：遗传学及进化意义
Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.
作者信息
Moriuchi J, Moriuchi T, Silver J
出版信息
Proc Natl Acad Sci U S A. 1985 May;82(10):3420-4. doi: 10.1073/pnas.82.10.3420.
Abstract
Three families of human Ia molecules, DP, DQ, and DR, have previously been defined. A cDNA clone, pDSH-9.1, encoding the alpha chain of a DQ molecule derived from an HLA-DRw9 homozygous cell line has been isolated and sequenced. Comparison of the nucleotide and predicted protein sequence to those of other DQ alpha subunits reveals that DQ alpha subunits derived from DR4, -7, and -9 cells are very similar to each other but quite different from a DQ alpha subunit derived from a DRw6 cell line. These studies suggest that certain Ia haplotypes have a common evolutionary history. Furthermore, in the context of current serologic and biochemical knowledge, they suggest that the gene encoding the DQ alpha subunit is in strong linkage disequilibrium with the DR locus.
摘要
先前已定义了人类Ia分子的三个家族，即DP、DQ和DR。已分离并测序了一个cDNA克隆pDSH-9.1，它编码来自HLA-DRw9纯合细胞系的一个DQ分子的α链。将该核苷酸和预测的蛋白质序列与其他DQα亚基的序列进行比较，发现源自DR4、-7和-9细胞的DQα亚基彼此非常相似，但与源自DRw6细胞系的DQα亚基有很大不同。这些研究表明，某些Ia单倍型有共同的进化史。此外，结合当前的血清学和生物化学知识，这些研究表明，编码DQα亚基的基因与DR基因座处于强连锁不平衡状态。
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