Frey M, Gruber H, Stransky G, Havel M
Department of Plastic and Reconstructive Surgery, Second Surgical University Clinic of Vienna, Austria.
J Reconstr Microsurg. 1985 Oct;2(1):33-43. doi: 10.1055/s-2007-1007043.
The time course of alterations in muscle transfers with microneurovascular anastomoses was studied in 17 rabbits. The left rectus femoris muscle was transferred to the right side. For comparison, in some animals the right rectus femoris muscle was transferred from the right to the left side, but without vascular repair. Two, seven, 14, 21, and 30 days after transfer, the electric excitability, macroscopic appearance, histology, histochemistry, ultrastructure, and activity of muscle enzymes were assessed. In the transfers with microneurovascular anastomoses, almost all muscle fibers survived. Alterations were limited to those typical of a denervation-reinnervation process. Contrary to this, only a few atrophic fibers survived in the periphery of the transfers without vascular repair. By far, the greater central part underwent necrosis. A considerable amount of connective tissue developed. These results clearly show the functional superiority of microsurgically vascularized muscle transfers over those without vascular anastomoses. Excellent functional recovery is possible because the process of complete degeneration and consecutive regeneration, with inevitable augmentation of connective tissue, is prevented by the performance of vascular anastomoses.
在17只兔子身上研究了带显微神经血管吻合的肌肉移植的变化时间进程。将左侧股直肌转移至右侧。作为对照，在一些动物中，将右侧股直肌从右侧转移至左侧，但不进行血管修复。在转移后2天、7天、14天、21天和30天，评估肌肉的电兴奋性、宏观外观、组织学、组织化学、超微结构和肌肉酶活性。在带显微神经血管吻合的移植中，几乎所有肌纤维都存活。变化仅限于去神经再支配过程的典型变化。与此相反，在没有血管修复的移植周边，只有少数萎缩纤维存活。到目前为止，更大的中央部分发生了坏死。形成了大量结缔组织。这些结果清楚地表明，显微外科血管化肌肉移植在功能上优于无血管吻合的移植。由于进行了血管吻合，防止了完全变性和连续再生过程以及不可避免的结缔组织增生，从而有可能实现出色的功能恢复。
