Guelinckx P J, Carlson B M, Faulkner J A
Department of Plastic and Reconstructive Surgery, University of Leuven, Belgium.
J Reconstr Microsurg. 1992 Nov;8(6):481-9. doi: 10.1055/s-2007-1006734.
In 34 female white rabbits, rectus femoris (RFM) muscles were grafted with immediate anastomoses of the vasculature (VA) and with nerves either left intact (NI-VA) or with nerves repaired (NR-VA). The purpose of the study was to compare the morphologic changes that occur in NI-VA grafts and NR-VA grafts from 8 to 120 days after grafting. After 8 days, nearly complete survival of all muscle fibers was found. The muscle mass and single fiber cross-sectional area (CSA) of the NI-VA group remained near control values for the first 30 days and then declined to 82 percent and 62 percent of the control values, respectively. Little evidence of morphologic disruption was observed. The NR-VA grafts displayed a significant denervation atrophy within the first 15 days, with relative values 67 percent of the control value for mean mass and 53 percent for single fiber CSA. By 120 days, mass and CSA recovered to 80 percent and 62 percent of control values. Although the similarity of the deficits in the nerve-intact and nerve-repaired grafts suggest that tenotomy and repair, rather than innervation, were the major limitations, the mechanism was not resolved.
在34只雌性白兔中，对股直肌（RFM）进行移植，同时立即吻合血管（VA），神经要么保持完整（NI-VA），要么进行修复（NR-VA）。本研究的目的是比较移植后8至120天NI-VA移植物和NR-VA移植物中发生的形态学变化。8天后，发现所有肌纤维几乎完全存活。NI-VA组的肌肉质量和单纤维横截面积（CSA）在最初30天内接近对照值，然后分别降至对照值的82%和62%。未观察到明显的形态学破坏迹象。NR-VA移植物在最初15天内出现明显的去神经萎缩，平均质量的相对值为对照值的67%，单纤维CSA为对照值的53%。到120天时，质量和CSA恢复到对照值的80%和62%。尽管神经完整和神经修复移植物中缺陷的相似性表明，切断术和修复而非神经支配是主要限制因素，但该机制尚未明确。
