Guelinckx P J, Dom R, Bex M, Boeckx W D, Gruwez J A
Br J Plast Surg. 1984 Oct;37(4):584-95. doi: 10.1016/0007-1226(84)90155-3.
To study the effect of vascular repair on muscle transplants, rectus femoris muscles in rabbits were grafted orthotopically with and without microsurgical blood vessel repair. The function and structure of the grafts were evaluated 90 days after operation. Contractile properties were measured in vivo. Muscle biopsies were stained for nerve and motor end-plate regeneration. The twitch tension and maximal tetanic tension returned respectively to 32 +/- 6% and 32 +/- 7% of control values in the vascular transplants. In the avascular transplants twitch tension and maximal tetanic tension were respectively 6 +/- 1% and 8 +/- 1% of control values. Poor regeneration of muscle fibres, infection, fibrosis and immature reinnervation were the reasons for failure of avascular transplants. The avascular muscle grafts had insufficient contractile properties and were more static than dynamic. In conclusion, large avascular muscle grafts should be avoided because of the likelihood of poor revascularisation with extensive ischaemic necrosis, resulting in scar tissue.
为研究血管修复对肌肉移植的影响，将兔股直肌在有或无微血管修复的情况下原位移植。术后90天评估移植物的功能和结构。在体内测量收缩特性。对肌肉活检组织进行神经和运动终板再生染色。血管化移植组的抽搐张力和最大强直张力分别恢复至对照值的32±6%和32±7%。在非血管化移植组中，抽搐张力和最大强直张力分别为对照值的6±1%和8±1%。肌纤维再生不良、感染、纤维化和神经再支配不成熟是导致非血管化移植失败的原因。非血管化肌肉移植物的收缩特性不足，更多的是静态而非动态。总之，应避免使用大的非血管化肌肉移植物，因为可能出现血管再通不良并伴有广泛的缺血性坏死，从而导致瘢痕组织形成。
