School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Qingmao Technology (Shenzhen) Co., LTD, Shenzhen, China.
Macromol Biosci. 2024 Sep;24(9):e2400093. doi: 10.1002/mabi.202400093. Epub 2024 Jun 3.
Cardiovascular disease is one of the diseases with the highest morbidity and mortality rates worldwide, and coronary artery bypass grafting (CABG) is a fast and effective treatment. More researchers are investigating in artificial blood vessels due to the limitations of autologous blood vessels. Despite the availability of large-diameter vascular grafts (Ø > 6 mm) for clinical use, small-diameter vascular grafts (Ø < 6 mm) have been a challenge for researchers to overcome in recent years. Vascular grafts made of polyvinyl alcohol (PVA) and PVA-based composites have excellent biocompatibility and mechanical characteristics. In order to gain a clearer and more specific understanding of the progress in PVA vascular graft research, particularly regarding the preparation methods, principles, and functionality of PVA vascular graft, this article discusses the mechanical properties, biocompatibility, blood compatibility, and other properties of PVA vascular graft prepared or enhanced with different blends using various techniques that mimic natural blood vessels. The findings reveal the feasibility and promising potential of PVA or PVA-based composite materials as vascular grafts.
心血管疾病是全球发病率和死亡率最高的疾病之一，冠状动脉旁路移植术（CABG）是一种快速有效的治疗方法。由于自体血管的局限性，越来越多的研究人员正在研究人工血管。尽管有大直径血管移植物（Ø>6mm）可供临床使用，但近年来小直径血管移植物（Ø<6mm）一直是研究人员面临的挑战。由聚乙烯醇（PVA）和基于 PVA 的复合材料制成的血管移植物具有优异的生物相容性和机械特性。为了更清楚、更具体地了解 PVA 血管移植物研究的进展，特别是关于 PVA 血管移植物的制备方法、原理和功能，本文讨论了使用各种技术制备或增强的 PVA 血管移植物的机械性能、生物相容性、血液相容性和其他特性，这些技术模拟了天然血管。研究结果表明，PVA 或基于 PVA 的复合材料作为血管移植物具有可行性和广阔的应用前景。
