Huang Min, Zhang Honglong, Wang Haiping, Niu Jingping, Luo Bin, Wu Gang, Li Xun, Yan Jun
The First School of Clinical Medical, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430061, People's Republic of China.
Biol Trace Elem Res. 2025 Mar;203(3):1241-1250. doi: 10.1007/s12011-024-04243-z. Epub 2024 May 27.
In this study, we explored how cadmium and lead co-exposure affects sleep status among residents of a polluted area and nature reserve in rural northwestern China. Cadmium and lead levels were measured using blood samples, and sleep status was evaluated using sleep questionnaires, with the main sleep indicators including sleep duration, sleep quality, bedtime, and staying up. Furthermore, cadmium-lead co-exposure levels were divided into three groups: high exposure, medium exposure, and low exposure. Subjects in the contaminated area had significantly higher exposure levels (p < 0.001) and more negative sleep indicators (p < 0.01). Significant differences were found for all four sleep indicators in the high exposure group compared to the low exposure group (p < 0.01). Moreover, the overall evaluation of sleep status with high cadmium-lead co-exposure had a negative impact. Our data suggest that cadmium-lead co-exposure has a negative effect on sleep status and may have a synergistic effect on sleep.
在本研究中，我们探究了镉和铅共同暴露如何影响中国西北农村污染地区和自然保护区居民的睡眠状况。通过采集血样测量镉和铅水平，使用睡眠问卷评估睡眠状况，主要睡眠指标包括睡眠时间、睡眠质量、就寝时间和熬夜情况。此外，镉铅共同暴露水平分为高暴露、中暴露和低暴露三组。污染地区的受试者暴露水平显著更高（p < 0.001），睡眠指标更差（p < 0.01）。与低暴露组相比，高暴露组的所有四项睡眠指标均存在显著差异（p < 0.01）。此外，镉铅高共同暴露对睡眠状况的总体评估有负面影响。我们的数据表明，镉铅共同暴露对睡眠状况有负面影响，且可能对睡眠有协同作用。
