Zhang Yijia, Chen Cheng, Luo Juhua, Dibaba Daniel T, Fly Alyce D, Haas David M, Shikany James M, Kahe Ka
Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA.
Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Eur J Nutr. 2022 Mar;61(2):753-762. doi: 10.1007/s00394-021-02682-1. Epub 2021 Sep 19.
To examine the associations of long-chain omega-3 polyunsaturated fatty acids (LCω3PUFA) intake with sleep quality and duration in a cohort of American young adults, and to explore whether the associations of interest are modified by selenium (Se) and/or mercury (Hg) status.
The study sample consisted of 3964 men and women from the longitudinal Coronary Artery Risk Development in Young Adults (CARDIA) study, aged 25.0 ± 3.6 at baseline. Intake of LCω3PUFA was assessed using an interviewer-administered dietary history questionnaire at baseline (1985-1986), Y7 (1992-1993), and Y20 (2005-2006). Toenail Se and Hg concentrations were quantified at Y2 (1987-1988). The outcomes were self-reported sleep quality and sleep duration measured by one question for each at Y15 (2000-2001) and Y20. Generalized estimating equation was used to examine the association between cumulative average intake of LCω3PUFA and sleep measures. Restricted cubic spline was performed to explore the potential non-linear associations of interest. Se and Hg were dichotomized by their median values to examine the potential effect modification of Se and/or Hg.
We did not observe any significant associations (linear or non-linear) of LCω3PUFA intake with either sleep quality or duration. Also, no significant association was observed in any subgroup classified by toenail Se and/or Hg concentrations. Similarly, sensitivity analysis indicated that the null associations between LCω3PUFA intake and sleep quality or duration persisted across subgroups classified by race, gender, obesity, or having small children.
Findings from this longitudinal analysis did not support the hypothesis that LCω3PUFA intake is associated with sleep quality or sleep duration.
研究美国年轻成年人队列中长链ω-3多不饱和脂肪酸（LCω3PUFA）摄入量与睡眠质量和时长的关联，并探讨感兴趣的关联是否因硒（Se）和/或汞（Hg）状态而改变。
研究样本包括来自青年成人冠状动脉风险发展纵向研究（CARDIA）的3964名男性和女性，基线时年龄为25.0±3.6岁。在基线（1985 - 1986年）、Y7（1992 - 1993年）和Y20（2005 - 2006年）时，使用访员-administered饮食史问卷评估LCω3PUFA的摄入量。在Y2（1987 - 1988年）时对趾甲中的Se和Hg浓度进行定量。结局指标是在Y15（2000 - 2001年）和Y20时通过每个问题自我报告的睡眠质量和睡眠时间。使用广义估计方程研究LCω3PUFA累积平均摄入量与睡眠指标之间的关联。进行受限立方样条分析以探索感兴趣的潜在非线性关联。将Se和Hg按中位数进行二分，以检查Se和/或Hg的潜在效应修饰。
我们未观察到LCω3PUFA摄入量与睡眠质量或时长之间存在任何显著关联（线性或非线性）。此外，在按趾甲Se和/或Hg浓度分类的任何亚组中均未观察到显著关联。同样，敏感性分析表明，LCω3PUFA摄入量与睡眠质量或时长之间的零关联在按种族、性别、肥胖或有小孩分类的亚组中均持续存在。
这项纵向分析的结果不支持LCω3PUFA摄入量与睡眠质量或睡眠时间相关的假设。
