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垂体功能减退症管理的进展、挑战与展望。

Progress, challenges and perspectives in the management of hypopituitarism.

机构信息

Endocrine Division (SEMPR), Department of Internal Medicine, Federal University of parana, Curitiba, Brazil.

SEMPR, Serviço de Endocrinologia e Metabologia do Hospital de Clínicas da Universidade Federal do Paraná, Avenida Agostinho Leão Junior, 285, 80030-110, Curitiba, PR, Brazil.

出版信息

Rev Endocr Metab Disord. 2024 Jun;25(3):453-455. doi: 10.1007/s11154-024-09889-7. Epub 2024 May 27.

DOI:10.1007/s11154-024-09889-7
PMID:38801648
Abstract

Hypopituitarism is a rare endocrine disorder characterized by insufficient hormone secretion from the pituitary gland. This condition leads to deficient production of one or more pituitary hormones, including growth hormone (GH), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), adrenocorticotropic hormone (ACTH), and antidiuretic hormone (ADH), also called arginine vasopressin (AVP). Symptoms vary widely and are often not, late recognized.Diagnosis typically involves a thorough clinical evaluation, hormone level assessments, and neuroimaging studies to identify underlying causes. Treatment aims to replace deficient hormones and address the underlying cause and related complications when possible. In this special issue we address diagnosis, comorbidities, and management of hypopituitarism. We hope that it will help healthcare professionals to manage their patients.

摘要

垂体功能减退症是一种罕见的内分泌疾病,其特征是垂体激素分泌不足。这种情况会导致一种或多种垂体激素的产生不足,包括生长激素(GH)、促甲状腺激素(TSH)、促黄体生成素(LH)、促卵泡激素(FSH)、促肾上腺皮质激素(ACTH)和抗利尿激素(ADH),也称为精氨酸血管加压素(AVP)。症状差异很大,且常常未被及时识别。诊断通常包括全面的临床评估、激素水平评估和神经影像学研究,以确定潜在病因。治疗旨在补充缺乏的激素,并尽可能针对潜在病因和相关并发症进行治疗。在本期特刊中,我们探讨了垂体功能减退症的诊断、合并症和管理。我们希望它能帮助医疗保健专业人员管理他们的患者。

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本文引用的文献

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Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism.垂体功能减退症的管理:来自巴西内分泌学会和代谢学会的观点。
Arch Endocrinol Metab. 2021 Nov 1;65(2):212-230. doi: 10.20945/2359-3997000000335. Epub 2021 Feb 24.
2
Human pituitary development and application of iPSCs for pituitary disease.人垂体发育和 iPSCs 在垂体疾病中的应用。
Cell Mol Life Sci. 2021 Mar;78(5):2069-2079. doi: 10.1007/s00018-020-03692-8. Epub 2020 Nov 18.
3
Fertility issues in aggressive pituitary tumors.
侵袭性垂体瘤的生育问题。
Rev Endocr Metab Disord. 2020 Jun;21(2):225-233. doi: 10.1007/s11154-019-09530-y.
4
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE.美国临床内分泌医师协会和美国内分泌学会成人生长激素缺乏症管理指南以及儿科向成人保健过渡患者的指南。
Endocr Pract. 2019 Nov;25(11):1191-1232. doi: 10.4158/GL-2019-0405.
5
Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline.成人垂体功能减退症的激素替代治疗:内分泌学会临床实践指南
J Clin Endocrinol Metab. 2016 Nov;101(11):3888-3921. doi: 10.1210/jc.2016-2118. Epub 2016 Oct 13.
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Mortality in patients with pituitary disease.垂体疾病患者的死亡率。
Endocr Rev. 2010 Jun;31(3):301-42. doi: 10.1210/er.2009-0033. Epub 2010 Jan 19.