Sun Yehao, Prabhu Prital, Rahman Ryan, Li Dongmei, McIntosh Scott, Rahman Irfan
Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, United States.
Department of Clinical & Translational Research, University of Rochester Medical Center, Rochester, NY, United States.
Online J Public Health Inform. 2024 May 27;16:e51991. doi: 10.2196/51991.
Recently, the US Food and Drug Administration implemented enforcement priorities against all flavored, cartridge-based e-cigarettes other than menthol and tobacco flavors. This ban undermined the products' appeal to vapers, so e-cigarette manufacturers added flavorants of other attractive flavors into tobacco-flavored e-cigarettes and reestablished appeal.
This review aims to analyze the impact of the addition of other flavorants in tobacco-flavored e-cigarettes on both human and public health issues and to propose further research as well as potential interventions.
Searches for relevant literature published between 2018 and 2023 were performed. Cited articles about the toxicity of e-cigarette chemicals included those published before 2018, and governmental websites and documents were also included for crucial information.
Both the sales of e-cigarettes and posts on social media suggested that the manufacturers' strategy was successful. The reestablished appeal causes not only a public health issue but also threats to the health of individual vapers. Research has shown an increase in toxicity associated with the flavorants commonly used in flavored e-cigarettes, which are likely added to tobacco-flavored e-cigarettes based on tobacco-derived and synthetic tobacco-free nicotine, and these other flavors are associated with higher clinical symptoms not often induced solely by natural, traditional tobacco flavors.
The additional health risks posed by the flavorants are pronounced even without considering the toxicological interactions of the different tobacco flavorants, and more research should be done to understand the health risks thoroughly and to take proper actions accordingly for the regulation of these emerging products.
最近，美国食品药品监督管理局对除薄荷醇和烟草口味外的所有调味盒式电子烟实施了执法优先措施。这项禁令削弱了产品对电子烟使用者的吸引力，因此电子烟制造商在烟草味电子烟中添加了其他诱人口味的调味剂，并重新建立了吸引力。
本综述旨在分析在烟草味电子烟中添加其他调味剂对人类健康和公共卫生问题的影响，并提出进一步的研究以及潜在的干预措施。
检索了2018年至2023年间发表的相关文献。关于电子烟化学物质毒性的引用文章包括2018年之前发表的文章，政府网站和文件也被纳入以获取关键信息。
电子烟的销售情况和社交媒体上的帖子都表明制造商的策略是成功的。重新建立的吸引力不仅引发了公共卫生问题，也对电子烟使用者个人的健康构成了威胁。研究表明，与调味电子烟中常用的调味剂相关的毒性有所增加，这些调味剂可能被添加到基于烟草衍生和合成无烟草尼古丁的烟草味电子烟中，而且这些其他口味与更高的临床症状相关，而这些症状通常不是由天然传统烟草口味单独引起的。
即使不考虑不同烟草调味剂的毒理学相互作用，调味剂带来的额外健康风险也很明显，应该进行更多的研究以全面了解健康风险，并相应地采取适当行动来监管这些新兴产品。
