Mohr W, Kuhn C, Pelster B, Wessinghage D
Abteilung Pathologie, Universität Ulm, Federal Republic of Germany.
Rheumatol Int. 1985;5(6):273-7. doi: 10.1007/BF00541355.
The occurrence of the S-100 protein was studied in normal and pathological cartilage from patients with osteoarthrosis and rheumatoid arthritis. In normal cartilage all cells of the different zones exhibit immunoreactivity for this protein. An identical distribution is observed in cases of osteoarthrosis and rheumatoid arthritis. Cellular pannus tissue usually is devoid of the S-100 protein. However, if chondroid metaplasia occurs in this tissue the cells become positive for the S-100 protein. From these results it is concluded that a chondroid metaplasia not only leads to a matrix comparable to cartilage but also contains cells that gain further characteristics of original chondrocytes.
研究了骨关节炎和类风湿性关节炎患者正常及病理状态下软骨中S-100蛋白的出现情况。在正常软骨中，不同区域的所有细胞对该蛋白均表现出免疫反应性。在骨关节炎和类风湿性关节炎病例中观察到相同的分布情况。细胞性血管翳组织通常缺乏S-100蛋白。然而，如果该组织发生软骨样化生，细胞会对S-100蛋白呈阳性反应。从这些结果可以得出结论，软骨样化生不仅导致形成类似于软骨的基质，而且还包含获得原始软骨细胞进一步特征的细胞。
