饮食镁与首次硬动脉粥样硬化性心血管疾病事件 10 年风险之间的关联。

Association between dietary magnesium and 10-year risk of a first hard atherosclerotic cardiovascular disease event.

机构信息

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Beijing, China; Academy of Integration of Chinese and Western Medicine, Peking University Health Science Center, Beijing, China; National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Am J Med Sci. 2024 Oct;368(4):355-360. doi: 10.1016/j.amjms.2024.05.014. Epub 2024 May 26.

DOI:10.1016/j.amjms.2024.05.014

PMID:38801946

Abstract

BACKGROUND

To test whether dietary magnesium is associated with 10-year risk of a first hard atherosclerotic cardiovascular disease event.

METHODS

In this cross-sectional study, a total of 2980 participants, aged 40 to 79 years, from the National Health and Nutrition Examination Survey 1999-2018 were analyzed. The association between dietary magnesium and 10-year risk of a first hard atherosclerotic cardiovascular disease (ASCVD) event was assessed following adjustment for clinical risk factors, including sex, age, race, educational level, body mass index (BMI), alcohol drinking, smoking, systolic blood pressure (SBP), diastolic blood pressure (DBP), hypertension treated or not, diabetes and low density lipoprotein cholesterol (LDL-C), total energy and dietary fiber. We performed multivariate linear regression models and smooth curve fittings to evaluate the associations between dietary magnesium and 10-year risk of a first hard atherosclerotic cardiovascular disease event.

RESULTS

We observed a significant inverse association between dietary magnesium and predicted 10-year risk of a first hard atherosclerotic cardiovascular disease event (β=-0.01, [95% CI: -0.01, -0.00], P = 0.0256). We divided the 10-year risk into two categories, with a statistically significant reduction of ASCVD risk when the 10-year risk ≥7.5% (β=-0.01, [95% CI: -0.01, -0.00], P = 0.0440).

CONCLUSIONS

Dietary magnesium intake was inversely associated with the predicted 10-year risk of a first hard atherosclerotic cardiovascular disease event.

摘要

背景

检测饮食镁元素与首次发生硬性动脉粥样硬化心血管疾病事件的 10 年风险之间的相关性。

方法

在这项横断面研究中，共分析了 2980 名年龄在 40 至 79 岁之间的 1999-2018 年国家健康和营养调查参与者。校正临床危险因素（包括性别、年龄、种族、教育程度、体重指数（BMI）、饮酒、吸烟、收缩压（SBP）、舒张压（DBP）、高血压治疗或未治疗、糖尿病和低密度脂蛋白胆固醇（LDL-C）、总能量和膳食纤维）后，评估饮食镁元素与首次发生硬性动脉粥样硬化心血管疾病（ASCVD）事件的 10 年风险之间的关系。我们进行了多元线性回归模型和光滑曲线拟合，以评估饮食镁元素与首次发生硬性动脉粥样硬化心血管疾病事件的 10 年风险之间的关系。

结果

我们观察到饮食镁元素与预测的首次发生硬性动脉粥样硬化心血管疾病事件的 10 年风险之间存在显著的负相关关系（β=-0.01，[95% CI：-0.01，-0.00]，P=0.0256）。我们将 10 年风险分为两类，当 10 年风险≥7.5%时，ASCVD 风险显著降低（β=-0.01，[95% CI：-0.01，-0.00]，P=0.0440）。