Qu Hua, Long Lin-Zi, Chen Li, Wu Han-Tao, Fu Chang-Geng, Zhang Shan-Shan
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
National Clinical Research Center for Chinese Medicine Cardiology, Beijing, China.
Front Cardiovasc Med. 2023 Jan 9;9:994329. doi: 10.3389/fcvm.2022.994329. eCollection 2022.
Whether Triglyceride-glucose (TyG) index is associated with 10-year risk of a first hard atherosclerotic cardiovascular disease (ASCVD) event in the United States remains unclear.
In this cross-sectional study, the participants, ranged from 40 to 79 years old, were from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. TyG index was the independent variable and 10-year risk of a first hard ASCVD was the dependent variable. The other variables, such as age, gender, race, body mass index (BMI), hypertension treatment states, smoking states and low-density lipoprotein cholesterol (LDL-C) et al. were considered as the potential confounding factors. Multivariate linear regression models and smooth curve fittings were used to evaluate the association between TyG index and 10-year risk of a first hard ASCVD event.
A total of 2,142 participants were included in the analysis. The results showed that TyG index was associated with an increased 10-year risk of a first hard ASCVD event [β = 2.208, 95% (1.716, 2.700), < 0.00001]. The association had statistical significance in both men [β = 3.862 95% CI (3.274, 4.450), < 0.00001] and women [β = 1.067, 95% CI (0.286, 1.849), = 0.00756)] according to subgroup analysis. Smooth curve fittings revealed that TyG index was linearly associated with 10-year risk of ASCVD in both male and female.
Triglyceride-glucose index was associated with an increased 10-year risk of a first hard ASCVD event in the United States, suggesting it is necessary to monitor and control an appropriate range of TyG index.
甘油三酯-葡萄糖（TyG）指数是否与美国首次发生严重动脉粥样硬化性心血管疾病（ASCVD）事件的10年风险相关尚不清楚。
在这项横断面研究中，参与者年龄在40至79岁之间，来自1999年至2018年的美国国家健康与营养检查调查（NHANES）。TyG指数为自变量，首次发生严重ASCVD的10年风险为因变量。其他变量，如年龄、性别、种族、体重指数（BMI）、高血压治疗状态、吸烟状态和低密度脂蛋白胆固醇（LDL-C）等被视为潜在的混杂因素。采用多元线性回归模型和平滑曲线拟合来评估TyG指数与首次发生严重ASCVD事件的10年风险之间的关联。
共有2142名参与者纳入分析。结果显示，TyG指数与首次发生严重ASCVD事件的10年风险增加相关[β = 2.208，95%（1.716，2.700），P < 0.00001]。根据亚组分析，该关联在男性[β = 3.862，95%CI（3.274，4.450），P < 0.00001]和女性[β = 1.067，95%CI（0.286，1.849），P = 0.00756]中均具有统计学意义。平滑曲线拟合显示，TyG指数与男性和女性ASCVD的10年风险均呈线性相关。
甘油三酯-葡萄糖指数与美国首次发生严重ASCVD事件的10年风险增加相关，提示有必要监测和控制TyG指数在适当范围。
