Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330000, Jiangxi Province, China.
Jiangxi Institute of Urology, Nanchang, 330000, Jiangxi Province, China.
Lipids Health Dis. 2024 May 27;23(1):158. doi: 10.1186/s12944-024-02150-9.
Recent interest in the Non-High Density to High Density Lipoprotein Cholesterol ratio (NHHR) has emerged due to its potential role in metabolic disorders. However, the connection between NHHR and the development of kidney stones still lacks clarity. The primary goal of this research is to explore how NHHR correlates with kidney stone incidence.
An analysis was conducted on the data collected by the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, focusing on adults over 20 years diagnosed with kidney stones and those with available NHHR values. Employing weighted logistic regression and Restricted Cubic Spline (RCS) models, NHHR levels' correlation with kidney stone risk was examined. Extensive subgroup analyses were conducted for enhanced reliability of the findings.
The findings indicate a heightened kidney stone risk for those at the highest NHHR levels relative to those at the lowest (reference group). A notable non-linear correlation of NHHR with kidney stone incidence has been observed, with a significant P-value (< 0.001), consistent across various subgroups.
A clear link exists between high NHHR levels and increased kidney stone risk in the American adult population. This study highlights NHHR's significance as a potential indicator in kidney stone formation.
由于非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）在代谢紊乱中的潜在作用，人们对其近来产生了浓厚的研究兴趣。然而，NHHR 与肾结石发展之间的联系仍不明确。本研究的主要目的是探讨 NHHR 与肾结石发病率之间的相关性。
对 2007 年至 2018 年期间开展的全国健康与营养调查（NHANES）数据进行分析，重点关注 20 岁以上被诊断为肾结石且 NHHR 值可用的成年人。采用加权逻辑回归和限制性三次样条（RCS）模型，分析 NHHR 水平与肾结石风险的相关性。进行了广泛的亚组分析，以提高研究结果的可靠性。
研究结果表明，与最低 NHHR 水平组（参照组）相比，NHHR 水平最高的个体肾结石风险更高。观察到 NHHR 与肾结石发病率之间存在显著的非线性相关性（P 值<0.001），且在不同亚组中具有一致性。
美国成年人中，高 NHHR 水平与肾结石风险增加之间存在明确的关联。本研究强调了 NHHR 作为肾结石形成的潜在指标的重要性。
