Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, 215300, China.
Department of Cardiology, Xuyi People's Hospital, Xuyi, Jiangsu, 211700, China.
Lipids Health Dis. 2024 Jun 21;23(1):187. doi: 10.1186/s12944-024-02171-4.
The ratio of non-high-density lipoprotein cholesterol (non-HDL-c) to high-density lipoprotein cholesterol (HDL-c) (NHHR) is a novel comprehensive lipid index. The aim of this study was to investigate the relationship between the NHHR and the prevalence of hyperuricaemia (HUA) in the adult population of the U.S.
This cross-sectional study collected data from the National Health and Nutrition Examination Survey (NHANES) (2007-2018). HUA was defined as a serum uric acid (SUA) concentration ≥ 7 mg/dL in men and ≥ 6 mg/dL in women. Multivariate logistic regression models and the restricted cubic spline (RCS) method were applied to examine the relationship between the NHHR and the risk of developing HUA. Subgroup analyses and interaction tests were also performed.
The prevalence of HUA increased with increasing NHHR values (9.01% vs. 13.38% vs. 17.31% vs. 25.79%, P < 0.001). The NHHR was independently correlated with the risk of developing HUA (OR = 1.10, 95% CI: 1.05-1.16; P < 0.001). Furthermore, the risk of developing HUA was significantly greater among individuals with the highest NHHR quartile than among those with the lowest NHHR quartile (OR = 1.94, 95% CI: 1.62-2.33; P < 0.001). This relationship was consistent across subgroups. According to the RCS analysis, an inverted U-shaped relationship existed between the NHHR and the risk of developing HUA.
The NHHR was closely associated with an increased risk of developing HUA. Further studies on the NHHR could be beneficial for preventing and treating HUA.
非高密度脂蛋白胆固醇（non-HDL-c）与高密度脂蛋白胆固醇（HDL-c）的比值（NHHR）是一种新的综合脂质指标。本研究旨在探讨美国成年人人群中 NHHR 与高尿酸血症（HUA）患病率之间的关系。
本横断面研究从国家健康和营养调查（NHANES）（2007-2018 年）中收集数据。HUA 定义为男性血清尿酸（SUA）浓度≥7mg/dL 和女性 SUA 浓度≥6mg/dL。应用多变量 logistic 回归模型和限制性立方样条（RCS）方法来检验 NHHR 与发生 HUA 的风险之间的关系。还进行了亚组分析和交互检验。
HUA 的患病率随着 NHHR 值的升高而增加（9.01% vs. 13.38% vs. 17.31% vs. 25.79%，P<0.001）。NHHR 与发生 HUA 的风险独立相关（OR=1.10，95%CI：1.05-1.16；P<0.001）。此外，NHHR 最高四分位的个体发生 HUA 的风险显著高于 NHHR 最低四分位的个体（OR=1.94，95%CI：1.62-2.33；P<0.001）。这种关系在各个亚组中都是一致的。根据 RCS 分析，NHHR 与发生 HUA 的风险之间存在倒 U 形关系。
NHHR 与发生 HUA 的风险增加密切相关。对 NHHR 的进一步研究可能有助于预防和治疗 HUA。
