School of Nursing, Zhejiang Chinese Medical University, Hangzhou, 310000, China.
Department of Nursing, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China.
J Orthop Surg Res. 2024 May 28;19(1):314. doi: 10.1186/s13018-024-04808-7.
Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. The present study conducted a systematic review and meta-analysis to investigate the relationship between SII and sarcopenia.
A literature search was performed in Web of Science, PubMed, Embase, Cochrane Library, CINAHL, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, and VIP Chinese Science and Technology Database, from inception to March 2024. Then, the literature quality was assessed. After the heterogeneity test, a random effects or fixed effects model was applied to establish the forest plot, and investigate the relationship between SII and sarcopenia. Then, the sensitivity analysis and publication bias were examined.
Nine articles, which included 18,634 adults, were analyzed. Sarcopenic adults had higher SII levels, when compared to non-sarcopenic adults (standardized mean difference [SMD] = 0.66, 95% confidence interval [CI] = 0.22 - 0.19, p = 0.003). The high SII level was associated to the increased risk of sarcopenia (odds ratio = 1.52, 95% CI = 1.09-2.13, p = 0.01). In addition, the subgroup analysis revealed that the SII levels were higher in the sarcopenic group, when compared to the non-sarcopenic group, in elderly adults, as well as in adults with or without gastrointestinal disorders. The analysis was robust with a low risk of publication bias.
SII is closely associated to sarcopenia. Sarcopenic adults had elevated SII levels. The high SII level increased the risk of sarcopenia. Large scale multi-center prospective studies are required to validate these study findings.
肌肉减少症与发病率和死亡率的增加有关。全身性免疫炎症指数（SII）与多种疾病相关。本研究进行了系统评价和荟萃分析，以调查 SII 与肌肉减少症之间的关系。
从建库到 2024 年 3 月，在 Web of Science、PubMed、Embase、Cochrane 图书馆、CINAHL、中国知网、中国生物医学文献数据库、万方数据库和维普中文科技期刊数据库中进行文献检索。然后，评估文献质量。在进行异质性检验后，采用随机效应或固定效应模型建立森林图，以探讨 SII 与肌肉减少症之间的关系。然后，进行敏感性分析和发表偏倚检验。
纳入了 9 篇文献，共包含 18634 名成年人。与非肌肉减少症成年人相比，肌肉减少症成年人的 SII 水平更高（标准化均数差 [SMD] = 0.66，95%置信区间 [CI] = 0.22-0.19，p = 0.003）。高 SII 水平与肌肉减少症风险增加相关（比值比 [OR] = 1.52，95%CI = 1.09-2.13，p = 0.01）。此外，亚组分析显示，与非肌肉减少症成年人相比，老年成年人以及有或没有胃肠道疾病的成年人中，肌肉减少症组的 SII 水平更高。分析结果稳健，发表偏倚风险较低。
SII 与肌肉减少症密切相关。肌肉减少症成年人的 SII 水平升高。高 SII 水平增加了肌肉减少症的风险。需要开展大规模多中心前瞻性研究来验证这些研究结果。
