Department of Clinical Sciences Lund, Dermatology, Lund University Skin Cancer Research group, Lund University, Lund, Sweden; Dermatology Department, Landskrona Hospital, Landskrona, Sweden.
Department of Clinical Sciences Lund, Dermatology, Lund University Skin Cancer Research group, Lund University, Lund, Sweden; Skåne University Hospital, Lund, Sweden.
Acta Derm Venereol. 2024 May 27;104:adv40112. doi: 10.2340/actadv.v104.40112.
Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data regarding all histopathologically verified, primary BCC tumours in Sweden from 2004 to 2017 was extracted from the Swedish BCC Registry. Risk of developing a subsequent BCC in relation to person-related factors was estimated with Cox regression analysis. Cumulative risk of BCC development after 1 or 3 earlier BCCs was estimated. In total, 39.9% of individuals with a registered BCC had at least 2 registered tumours. The risk of developing a subsequent BCC increased significantly in males, older age, and with residence in southern Sweden. The cumulative 5-year risk of developing an additional BCC after first diagnosis was approximately 30% in males and 27% in females and increased after multiple previous BCCs. This study showed the cumulative risk of a subsequent BCC to increase with a history of multiple BCCs, indicating the need for clinical surveillance in these individuals.
基底细胞癌（BCC）是一种常见的皮肤癌类型，已知患有该病的人存在罹患多个连续肿瘤的风险。由于缺乏全国性登记，迄今为止，对 BCC 多发性的研究一直具有挑战性。这项基于登记的队列研究旨在分析瑞典多发性基底细胞癌的发生情况，以及随后发生原发性 BCC 的危险因素。从 2004 年至 2017 年，从瑞典 BCC 登记处提取了所有经组织病理学证实的原发性 BCC 肿瘤的数据。使用 Cox 回归分析估计了与个体相关因素相关的发生后续 BCC 的风险。估计了在发生 1 个或 3 个先前 BCC 后的 BCC 发展的累积风险。在有登记的 BCC 的个体中，有 39.9%的人至少有 2 个登记的肿瘤。男性、年龄较大以及居住在瑞典南部会显著增加发生后续 BCC 的风险。首次诊断后发生另一个 BCC 的 5 年累积风险在男性中约为 30%，在女性中约为 27%，并且在发生多个先前的 BCC 后会增加。这项研究表明，随着 BCC 病史的增加，发生后续 BCC 的累积风险会增加，这表明需要对这些个体进行临床监测。
