Ciążyńska Magdalena, Pabianek Marta, Sławińska Martyna, Reich Adam, Lewandowski Bogumił, Szczepaniak Katarzyna, Ułańska Małgorzata, Nejc Dariusz, Brodowski Robert, Sobjanek Michał, Owczarek Witold, Kamińska-Winciorek Grażyna, Lange Dariusz, Słowińska Monika, Wróbel Katarzyna, Bieniek Andrzej, Woźniacka Anna, Pękala Anika, Kuncman Łukasz, Salińska Magdalena, Noweta Marcin, Skibińska Małgorzata, Narbutt Joanna, Ciążyński Karol, Lewandowska Marta, Dziankowska-Zaborszczyk Elżbieta, Lesiak Aleksandra
Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, ul. Pabianicka 62, 93-513 Lodz, Poland.
Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Lodz, 91-347 Lodz, Poland.
Cancers (Basel). 2022 Jun 23;14(13):3069. doi: 10.3390/cancers14133069.
Patients with diagnosed keratinocyte carcinomas (KCs) have an increased risk of subsequent skin cancers development. Current studies indicate that patients with subsequent tumors should be followed up regularly. However, none of the studies indicate the connection between the specific subtypes and an increased risk for further KCs development. The study assesses the differences in the risk of developing a subsequent skin cancer after a previous diagnosis of KC, especially considering individual types of skin malignances, and identifies potential factors associated with an increased risk of new cutaneous tumor describing non-invasive diagnosis and monitoring.
Pathology and medical records were examined to identify the characteristics of patients with multiple KCs diagnosed between 1999 and 2019.
The study group comprised 13,913 KCs occurring in 10,083 patients. Multiple KCs were observed in 2300 patients (22.8%). The analysis showed aggressive subtypes, multiple tumors, and male sex as significant prognostic factors.
The most crucial risk factors for developing subsequent KC are being of a male gender, an aggressive tumor subtype, and previous history of multiple skin cancers. Basal cell carcinoma subtypes, such as infiltrative basosquamous, with aggressive growth patterns predispose not only to increased risk for the recurrence but are also expected to be at higher risk of subsequent KCs.
已确诊为角质形成细胞癌（KC）的患者发生后续皮肤癌的风险增加。目前的研究表明，患有后续肿瘤的患者应定期随访。然而，没有一项研究表明特定亚型与KC进一步发展风险增加之间的联系。本研究评估了先前诊断为KC后发生后续皮肤癌的风险差异，特别是考虑到个体类型的皮肤恶性肿瘤，并确定了与新的皮肤肿瘤风险增加相关的潜在因素，描述了非侵入性诊断和监测。
检查病理和医疗记录，以确定1999年至2019年间诊断为多发性KC的患者的特征。
研究组包括10083例患者中发生的13913例KC。2300例患者（22.8%）观察到多发性KC。分析显示侵袭性亚型、多发肿瘤和男性是重要的预后因素。
发生后续KC的最关键风险因素是男性、侵袭性肿瘤亚型和既往多发性皮肤癌病史。基底细胞癌亚型，如浸润性基底鳞状细胞癌，具有侵袭性生长模式，不仅会增加复发风险，而且预计后续KC的风险也会更高。
