Burnett L, Basten A, Hensley W J
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Comput Appl Biosci. 1985 Dec;1(4):241-7. doi: 10.1093/bioinformatics/1.4.241.
A new method of access has been devised for biologists requiring the use of computer programs offering high-resolution analysis and comparison of nucleotide sequence data. The strategy involves the development of a pair of computer programs, called SEQANAL and SEQTALK, designed to operate in tandem. SEQANAL is a large and complex program intended to be used to discover regions of internal repeats and dyad symmetries within one sequence, or regions of homology, complementarity or optimal alignment between two sequences. Three algorithms are supported: those of Staden (1977, 1978); of Korn et al. (1977); Queen and Korn (1980); and the newly-described exhaustive tree-searching algorithm of Burnett et al. (1985, 1986). The SEQTALK program is a small, portable, interactive, front-end program with which the user can specify the instructions to control the SEQANAL program. Together, the SEQANAL and SEQTALK programs permit analyses to be performed at a remote facility on a mainframe computer under the complete control of a distant user equipped with minimal computing facilities, and without needing networking facilities.
对于需要使用提供核苷酸序列数据高分辨率分析和比较功能的计算机程序的生物学家，已经设计出一种新的访问方法。该策略涉及开发一对名为SEQANAL和SEQTALK的计算机程序，它们设计为协同运行。SEQANAL是一个大型复杂程序，旨在用于发现一个序列内的内部重复和二元对称区域，或两个序列之间的同源性、互补性或最佳比对区域。支持三种算法：Staden（1977年、1978年）的算法；Korn等人（1977年）的算法；Queen和Korn（1980年）的算法；以及Burnett等人（1985年、1986年）新描述的穷举树搜索算法。SEQTALK程序是一个小型、便携式、交互式前端程序，用户可以使用它指定控制SEQANAL程序的指令。SEQANAL和SEQTALK程序一起允许在远程设施的大型计算机上进行分析，由配备最少计算设施的远程用户完全控制，并且无需网络设施。
