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面向分子生物学家的苹果II Pascal程序。

Apple II PASCAL programs for molecular biologists.

作者信息

Malthiery B, Bellon B, Giorgi D, Jacq B

出版信息

Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):569-79. doi: 10.1093/nar/12.1part2.569.

DOI:10.1093/nar/12.1part2.569
PMID:6320099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321071/
Abstract

A collection of PASCAL programs designed for the Apple II microcomputer is presented. These DNA sequence handling and analysis programs are interactive and may be used even by people with no computer experience. The package allows the user to enter a sequence from the keyboard, to modify it, to generate the reverse complement, to create new sequences from parts of other ones, to display or print sequences in various formats. Some analysis tasks are also performed: Translation, searches for restriction sites, for homology with subsequences, either perfect or with an adjustable match percentage. In addition, two programs are also included: The first one allows DNA data sequences generated with a BASIC program under the CP/M operating system to be used with these PASCAL programs. The second one is designed for the automatic assembly of DNA fragments sequences, obtained with the GILBERT-MAXAM or M13 techniques, into a complete sequence.

摘要

本文展示了一组为苹果II微型计算机设计的PASCAL程序。这些DNA序列处理和分析程序是交互式的，即使没有计算机经验的人也可以使用。该软件包允许用户从键盘输入序列、修改序列、生成反向互补序列、从其他序列的部分创建新序列、以各种格式显示或打印序列。还执行一些分析任务：翻译、搜索限制酶切位点、搜索与子序列的同源性，包括完全匹配或具有可调匹配百分比的同源性。此外，还包括两个程序：第一个程序允许在CP/M操作系统下用BASIC程序生成的DNA数据序列与这些PASCAL程序一起使用。第二个程序用于将通过吉尔伯特-马克萨姆或M13技术获得的DNA片段序列自动组装成完整序列。

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本文引用的文献

1
A convenient and adaptable package of DNA sequence analysis programs for microcomputers.一套适用于微型计算机的便捷且可适配的DNA序列分析程序包。
Nucleic Acids Res. 1982 Jan 11;10(1):51-9. doi: 10.1093/nar/10.1.51.
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Apple II software for M13 shotgun DNA sequencing.用于M13猎枪式DNA测序的苹果II软件。
Nucleic Acids Res. 1982 Jan 11;10(1):39-49. doi: 10.1093/nar/10.1.39.
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Microcomputer programs for DNA sequence analysis.用于DNA序列分析的微机程序。
Nucleic Acids Res. 1982 Jan 11;10(1):31-8. doi: 10.1093/nar/10.1.31.
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Steps toward computer analysis of nucleotide sequences.核苷酸序列计算机分析的步骤。
Science. 1980 Sep 19;209(4463):1322-8. doi: 10.1126/science.6251542.
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Sequence data handling by computer.计算机对序列数据的处理
Nucleic Acids Res. 1977 Nov;4(11):4037-51. doi: 10.1093/nar/4.11.4037.
6
Computer analysis of nucleic acid regulatory sequences.核酸调控序列的计算机分析。
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4401-5. doi: 10.1073/pnas.74.10.4401.

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