Department of Cardiovascular, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Endocrinology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
J Clin Lab Anal. 2022 Jan;36(1):e24097. doi: 10.1002/jcla.24097. Epub 2021 Nov 27.
Carotid atherosclerosis (CAS) is associated with increased cardiovascular risk and implicated in 20-30% of strokes.
504 patients were included in this study. The detailed medical history and the results of physical examination, carotid ultrasound examination, and routine laboratory tests were collected. Logistic regression analyses were conducted to analyze the relationship between the SUA and the presence of carotid plaques. And the relationship between SUA and the progression of CAS was analyzed by multiple linear regression. The effect of hormone replacement therapy (HRT) on CAS has also be evaluated.
412 patients (81.7%) had carotid plaques of different sizes by carotid ultrasound examination. We found a positive association between the level of SUA and the probability of having carotid plaque by univariate logistic regression (OR: 2.01, 95% CI: 1.83-2.19, p = 0.003). At 2 years post-discharge, we found that 1 mg/dL increase in SUA levels was expected to 0.946% increase in plaque score and 0.026 cm increase in carotid intima-media thickness, separately. Moreover, patients treated by long-term HRT (≥5 years) had a lower level of SUA and blood lipid and the less change of plaque score and carotid intima-media thickness than patients without HRT.
The presence and progression of CAS had significantly positive associations with the level of SUA. And the HRT may have the ability to prevent the presence and progression of CAS. However, the safety and long-term outcome of HRT on CAS should be evaluated in further studies.
颈动脉粥样硬化（CAS）与心血管风险增加有关，约占中风的 20-30%。
本研究纳入了 504 名患者。收集了详细的病史、体格检查结果、颈动脉超声检查和常规实验室检查结果。采用 logistic 回归分析探讨 SUA 与颈动脉斑块之间的关系。采用多元线性回归分析 SUA 与 CAS 进展之间的关系。并评估了激素替代治疗（HRT）对 CAS 的影响。
504 名患者中，有 412 名（81.7%）经颈动脉超声检查发现存在不同大小的颈动脉斑块。单因素 logistic 回归分析发现，SUA 水平与颈动脉斑块的发生呈正相关（OR：2.01，95%CI：1.83-2.19，p=0.003）。出院后 2 年，我们发现 SUA 水平每增加 1mg/dL，斑块评分预计增加 0.946%，颈动脉内膜中层厚度增加 0.026cm。此外，长期接受 HRT（≥5 年）的患者的 SUA 及血脂水平较低，斑块评分和颈动脉内膜中层厚度的变化也较小。
CAS 的发生和进展与 SUA 水平呈显著正相关。HRT 可能具有预防 CAS 发生和进展的能力。然而，HRT 对 CAS 的安全性和长期疗效仍需进一步研究评估。
