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紫外线过滤剂二苯甲酮 - 3对卤虫无节幼体和斑马鱼胚胎的毒性

Toxicity of UV Filter Benzophenone-3 in Brine Shrimp Nauplii () and Zebrafish () Embryos.

作者信息

Ortiz-Román Melissa I, Casiano-Muñiz Ileska M, Román-Velázquez Felix R

机构信息

Department of Chemistry, University of Puerto Rico, Mayaguez Campus, Mayaguez, PR 00681, USA.

出版信息

J Xenobiot. 2024 Apr 29;14(2):537-553. doi: 10.3390/jox14020032.

DOI:10.3390/jox14020032
PMID:38804285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11130858/
Abstract

The benzophenone (BP) family, including oxybenzone (BP-3), a prevalent sunscreen ingredient and environmental contaminant, has raised concerns since the year 2005. This study investigated oxybenzone toxicity in zebrafish () eleutheroembryos and brine shrimp () nauplii, focusing on the LC and developmental impacts. Zebrafish embryos (0.100-1.50 mg/L BP-3, 96 h) and (0.100-5.00 mg/L BP-3, 48 h) were tested with ultrasound-assisted emulsified liquid-phase microextraction (UA-ELPME) used for zebrafish tissue analysis. HPLC-DAD determined BP-3 concentrations (highest: 0.74 ± 0.13 mg/L). Although no significant zebrafish embryo mortality or hatching changes occurred, developmental effects were evident. Lethal concentrations were determined ( LC at 24 h = 3.19 ± 2.02 mg/L; embryos LC at 24 h = 4.19 ± 3.60 mg/L), with malformations indicating potential teratogenic effects. displayed intestinal tract alterations and embryos exhibited pericardial edema and spinal deformities. These findings highlight oxybenzone's environmental risks, posing threats to species and ecosystem health.

摘要

二苯甲酮（BP）家族，包括二苯甲酰甲烷（BP-3），一种常见的防晒成分和环境污染物，自2005年以来就引发了人们的关注。本研究调查了二苯甲酰甲烷对斑马鱼（）幼胚和卤虫（）无节幼体的毒性，重点关注半数致死浓度（LC）和发育影响。斑马鱼胚胎（0.100 - 1.50毫克/升BP-3，96小时）和卤虫（0.100 - 5.00毫克/升BP-3，48小时）采用超声辅助乳化液液微萃取（UA-ELPME）进行测试，用于斑马鱼组织分析。高效液相色谱 - 二极管阵列检测器（HPLC-DAD）测定BP-3浓度（最高：0.74 ± 0.13毫克/升）。虽然斑马鱼胚胎没有出现显著的死亡率或孵化变化，但发育影响明显。测定了致死浓度（24小时半数致死浓度 = 3.19 ± 2.02毫克/升；卤虫无节幼体24小时半数致死浓度 = 4.19 ± 3.60毫克/升），畸形表明存在潜在的致畸作用。卤虫出现肠道改变，斑马鱼胚胎表现出心包水肿和脊柱畸形。这些发现凸显了二苯甲酰甲烷的环境风险，对物种和生态系统健康构成威胁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/b97aab0555e4/jox-14-00032-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/b006fd42f883/jox-14-00032-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/796fa416be78/jox-14-00032-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/5355c75b5cf6/jox-14-00032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/e44c0b51ae50/jox-14-00032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/8324a0ca810f/jox-14-00032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/f88442f55f9a/jox-14-00032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/b97aab0555e4/jox-14-00032-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/b006fd42f883/jox-14-00032-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/796fa416be78/jox-14-00032-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/5355c75b5cf6/jox-14-00032-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/e44c0b51ae50/jox-14-00032-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/8324a0ca810f/jox-14-00032-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/f88442f55f9a/jox-14-00032-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4041/11130858/b97aab0555e4/jox-14-00032-g005.jpg

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