School of Chemical Engineering and Technology, Guangdong Industry Polytechnic, Guangzhou, China.
Guangdong Engineering Technical Research Center for Green Household Chemicals, Guangzhou, China.
Bull Environ Contam Toxicol. 2021 May;106(5):740-746. doi: 10.1007/s00128-021-03166-y. Epub 2021 Mar 12.
Benzophenone-3 (BP-3) is an important ultraviolet (UV)-screening agent using in cosmetics, however, the associated environmental pollution and the toxicity to organisms, particularly aquatic organisms, cannot be neglected. In this study, the potential risks posed to zebrafish when exposed to environmental residual concentrations of BP-3 were evaluated. Zebrafish embryos (F0) were exposed to 0, 0.056, 2.3, and 38 μg/L BP-3 until 42 days' post-fertilization (dpf). The effects of BP-3 on the sex ratio and gene expression of F0 zebrafish were investigated. In the F1 embryos, cumulative hatching rate, body length, and heartbeats were observed. The result showed that F0 and F1 exposure to concentrations of 0.056 and 38 μg/L BP-3 elicited stronger toxicity at 96 hpf than single generation exposures. Overall, our results provide a new understanding on the effects of low BP-3 concentration chronic exposure on sex ratio and offspring developmental toxicity of the F0 zebrafish.
二苯甲酮-3（BP-3）是一种重要的化妆品用紫外线（UV）屏蔽剂，但不能忽视其相关的环境污染和对生物体的毒性，特别是对水生生物的毒性。在本研究中，评估了环境残留浓度的 BP-3 暴露对斑马鱼造成的潜在风险。将斑马鱼胚胎（F0）暴露于 0、0.056、2.3 和 38μg/L BP-3 中，直到受精后 42 天（dpf）。研究了 BP-3 对 F0 斑马鱼性别比例和基因表达的影响。在 F1 胚胎中，观察累积孵化率、体长和心跳。结果表明，F0 和 F1 暴露于 0.056 和 38μg/L BP-3 浓度下，在 96 hpf 时的毒性强于单一世代暴露。总的来说，我们的结果提供了对低浓度 BP-3 慢性暴露对 F0 斑马鱼性别比例和后代发育毒性影响的新认识。
