Solé Puig Maria, Bustos Valenzuela Patricia, Romeo August, Supèr Hans
Unitat d'Avaluació de la Cognició, l'Atenció i l'Aprenentatge (ACAP), 08035 Barcelona, Spain.
Vision and Control of Action Group, Department of Cognition, Development and Educational Psychology, University of Barcelona, 08035 Barcelona, Spain.
Vision (Basel). 2024 Apr 24;8(2):25. doi: 10.3390/vision8020025.
Mild cognitive impairment (MCI) may progress to severe forms of dementia, so therapy is needed to maintain cognitive abilities. The neural circuitry for oculomotor control is closely linked to that which controls cognitive behavior. In this study, we tested whether training the oculomotor system with gaze-controlled video games could improve cognitive behavior in MCI patients. Patients played a simple game for 2-3 weeks while a control group played the same game using a mouse. Cognitive improvement was assessed using the MoCA screening test and CANTAB. We also measured eye pupil and vergence responses in an oddball paradigm. The results showed an increased score on the MoCA test specifically for the visuospatial domain and on the Rapid Visual Information Processing test of the CANTAB battery. Pupil responses also increased to target stimuli. Patients in the control group did not show significant improvements. This pilot study provides evidence for the potential cognitive benefits of gaze-controlled gaming in MCI patients.
轻度认知障碍（MCI）可能会发展为严重形式的痴呆症，因此需要进行治疗以维持认知能力。眼球运动控制的神经回路与控制认知行为的神经回路紧密相连。在本研究中，我们测试了使用注视控制的视频游戏训练眼球运动系统是否可以改善MCI患者的认知行为。患者玩了2至3周的简单游戏，而对照组使用鼠标玩相同的游戏。使用蒙特利尔认知评估量表（MoCA）筛查测试和剑桥神经心理测试自动化成套系统（CANTAB）评估认知改善情况。我们还在oddball范式中测量了眼瞳孔和聚散反应。结果显示，MoCA测试中，特别是在视觉空间领域的得分以及CANTAB电池组的快速视觉信息处理测试得分有所提高。瞳孔对目标刺激的反应也增加了。对照组的患者没有显示出明显改善。这项初步研究为注视控制游戏对MCI患者潜在的认知益处提供了证据。
