Sousa-Pinto Bernardo, Louis Gilles, Vieira Rafael J, Czarlewski Wienczyslawa, Anto Josep M, Amaral Rita, Sá-Sousa Ana, Brussino Luisa, Canonica G Walter, Loureiro Claudia Chaves, Cruz Alvaro A, Gemicioglu Bilun, Haahtela Tari, Kupczyk Maciej, Kvedariene Violeta, Larenas-Linnemann Desirée E, Pham-Thi Nhân, Puggioni Francesca, Regateiro Frederico S, Romantowski Jan, Sastre Joaquin, Scichilone Nicola, Taborda-Barata Luis, Ventura Maria Teresa, Agache Ioana, Bedbrook Anna, Benfante Alida, Bergmann Karl C, Bosnic-Anticevich Sinthia, Bonini Matteo, Boulet Louis-Philippe, Brusselle Guy, Buhl Roland, Cecchi Lorenzo, Charpin Denis, Costa Elisio M, Del Giacco Stefano, Jutel Marek, Klimek Ludger, Kuna Piotr, Laune Daniel, Makela Mika, Morais-Almeida Mario, Nadif Rachel, Niedoszytko Marek, Papadopoulos Nikolaos G, Papi Alberto, Pfaar Oliver, Rivero-Yeverino Daniela, Roche Nicolas, Samolinski Boleslaw, Shamji Mohamed H, Sheikh Aziz, Ulrik Charlotte Suppli, Usmani Omar S, Valiulis Arunas, Yorgancioglu Arzu, Zuberbier Torsten, Fonseca Joao A, Pétré Benoit, Louis Renaud, Bousquet Jean
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Faculty of Medicine, CINTESIS@RISE - Health Research Network, University of Porto, Porto, Portugal.
Clin Transl Allergy. 2024 Jun;14(6):e12358. doi: 10.1002/clt2.12358.
It is unclear how each individual asthma symptom is associated with asthma diagnosis or control.
To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.
In this cross-sectional study, we assessed real-world data using the MASK-air app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma.
We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma.
Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
目前尚不清楚每种个体哮喘症状与哮喘诊断或控制之间是如何关联的。
评估个体哮喘症状在哮喘患者识别中的表现及其与哮喘控制的关联。
在这项横断面研究中，我们使用MASK-air应用程序评估实际数据。我们比较了可能患有、可能患有或目前无哮喘的患者中五种哮喘症状（呼吸困难、喘息、胸闷、疲劳和夜间症状，通过变应性鼻炎和哮喘控制测试[CARAT]问卷进行评估）的出现频率。我们计算了每种症状的敏感性、特异性和预测值，并评估了每种症状与哮喘控制之间的关联（使用电子哮喘控制测试[ e-DASTHMA ]评分进行测量）。结果在经医生确诊为哮喘的患者样本中得到验证。
我们纳入了951名患者（2153次CARAT评估），其中468名可能患有哮喘，166名可能患有哮喘，317名无哮喘证据。喘息表现出最高的特异性（90.5%）和阳性预测值（90.8%）。在可能患有哮喘的患者中，呼吸困难和胸闷与哮喘控制的关联比其他症状更强。呼吸困难是敏感性最高的症状（76.1%），并且根据电子哮喘控制测试[ e-DASTHMA ]评估，它始终与哮喘控制相关。在评估经医生诊断为哮喘的患者时观察到了一致的结果。
喘息和胸闷是哮喘诊断中特异性最高的哮喘症状，而呼吸困难表现出最高的敏感性以及与哮喘控制的最强关联。
Zotero 插件
