Ghahtan Najmeh, Dehghan Niloofar, Ullah Mujib, Khoradmehr Arezoo, Habibi Hassan, Nabipour Iraj, Baghban Neda
Department of Medicinal Chemistry, Faculty of Chemistry, Shiraz University of Technology, Shiraz, Iran.
Bushehr University of Medical Sciences, Bushehr, Iran.
Nat Prod Res. 2025 Mar;39(5):1345-1358. doi: 10.1080/14786419.2024.2358387. Epub 2024 May 28.
This bibliometric review examines the current state of research on fucoidan, a sulphated polysaccharide found in brown seaweed species, and its potential for wound healing. The review included 58 studies that investigated fucoidan's effects on wound healing, revealing that it possesses anti-inflammatory and antioxidant properties that could aid in the healing process. Fucoidan was also found to promote cell proliferation, migration, and angiogenesis, essential for wound healing. However, the optimal dosage, treatment duration, safety, and efficacy of fucoidan in various wound types and patient populations still require further investigation. Additionally, advanced wound dressings like hydrogels have garnered significant attention for their potential in wound healing. While this review indicates promise for fucoidan as a natural wound healing compound, it underscores the need for additional clinical trials to determine its optimal use as a commercial therapeutic agent in wound healing.
这篇文献计量学综述考察了岩藻依聚糖（一种存在于褐藻物种中的硫酸化多糖）的研究现状及其在伤口愈合方面的潜力。该综述纳入了58项研究，这些研究调查了岩藻依聚糖对伤口愈合的影响，结果表明它具有抗炎和抗氧化特性，有助于伤口愈合过程。还发现岩藻依聚糖能促进细胞增殖、迁移和血管生成，这些对伤口愈合至关重要。然而，岩藻依聚糖在各种伤口类型和患者群体中的最佳剂量、治疗持续时间、安全性和疗效仍需进一步研究。此外，水凝胶等先进伤口敷料因其在伤口愈合方面的潜力而备受关注。虽然这篇综述表明岩藻依聚糖作为一种天然伤口愈合化合物具有前景，但它强调需要进行更多临床试验，以确定其作为伤口愈合商业治疗剂的最佳用途。
