Izuegbuna Ogochukwu O, Olawumi Hannah O, Agodirin Olayide S, Olatoke Samuel A
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
J Am Nutr Assoc. 2024 Sep-Oct;43(7):582-591. doi: 10.1080/27697061.2024.2353289. Epub 2024 May 28.
The lipid profile and atherogenic risk indices in Nigerian breast cancer patients are largely unknown. This study evaluated the lipid profile and atherogenic risk indices of breast cancer patients in Nigeria.
This study involved 45 primarily diagnosed breast cancer patients and 50 normal control subjects. Total cholesterol, triglyceride, and High-density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) was calculated according to Friedewald formula. Atherogenic index of plasma (AIP), Atherogenic coefficient (AC), TC/HDL-C (Castelli I) and LDL-C/HDL-C (Castelli II) risk indices were all calculated. The Framingham risk assessment was calculated and categorized.
The study group had significantly higher triglycerides (TG), and atherogenic indices than the control group ( < 0.001), while HDL-Cholesterol (HDL-C) was significantly lower in the study group ( < 0.001). Total cholesterol and LDL-Cholesterol (LDL-C) had a significant positive correlation with age ( = 0.283, < 0.018; = 0.272, < 0.023); TG was significantly positively correlated with systolic and diastolic blood pressure ( = 0.320. < 0.007; = 0.334, < 0.005); HDL-C had a significant negative correlation with BMI, systolic and diastolic blood pressure ( = -0.252, < 0.035; = -0.29, < 0.015; = -0.329, < 0.005). The lipid ratios (TC/HDL-C, LDL-C/HDL-C) were significantly positively correlated with body mass index (BMI), systolic and diastolic blood pressure. The Framingham Risk Score showed that only 2 subjects in the study group (4.4%) were at a high risk of having a cardiovascular event.
Breast cancer patients have a higher prevalence of dyslipidaemia, and cardiovascular risk than the normal population.
尼日利亚乳腺癌患者的血脂谱和动脉粥样硬化风险指数在很大程度上尚不明确。本研究评估了尼日利亚乳腺癌患者的血脂谱和动脉粥样硬化风险指数。
本研究纳入了45例初诊乳腺癌患者和50例正常对照者。检测了总胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL-C）。低密度脂蛋白胆固醇（LDL-C）根据Friedewald公式计算。计算了血浆动脉粥样硬化指数（AIP）、动脉粥样硬化系数（AC）、TC/HDL-C（Castelli I）和LDL-C/HDL-C（Castelli II）风险指数。计算并分类了弗明汉风险评估。
研究组的甘油三酯（TG）和动脉粥样硬化指数显著高于对照组（<0.001），而研究组的高密度脂蛋白胆固醇（HDL-C）显著低于对照组（<0.001）。总胆固醇和低密度脂蛋白胆固醇（LDL-C）与年龄呈显著正相关（=0.283，<0.018；=0.272，<0.023）；TG与收缩压和舒张压呈显著正相关（=0.320，<0.007；=0.334，<0.005）；HDL-C与体重指数、收缩压和舒张压呈显著负相关（=-0.252，<0.035；=-0.29，<0.015；=-0.329，<0.005）。血脂比值（TC/HDL-C、LDL-C/HDL-C）与体重指数（BMI）、收缩压和舒张压呈显著正相关。弗明汉风险评分显示，研究组中只有2名受试者（4.4%）有发生心血管事件的高风险。
乳腺癌患者血脂异常和心血管风险的患病率高于正常人群。
