Nakamura Y, Sato T, Nishimura G, Tanimura A, Takahashi Y, Hachisuka H, Masaike K, Yanai T, Hashimoto H
Cancer. 1985 Jan 1;55(1):103-7. doi: 10.1002/1097-0142(19850101)55:1<103::aid-cncr2820550117>3.0.co;2-k.
A case of intracranial malignant teratoma found in a 27-year-old man was reported. This unique tumor was found in the right frontal lobe separated from the pineal region and revealed various tissue components such as stratified squamous epithelium, glandular tissues, neuron, glia, ependyma, fibromuscular tissue, cartilage, bone, hemangiomatous lesion, melanin-laden cells, and some germ cell components. An immunohistochemical study demonstrated the presence of S-100 protein, glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and Factor VIII in some tumourous components. In particular, the distribution of S-100 protein in some germ cells suggested the possibility of the neuroectodermal origin of the germ cells or, alternatively, differentiation to the neuroectoderm.
报告了一例在一名27岁男性中发现的颅内恶性畸胎瘤。这种独特的肿瘤位于右额叶，与松果体区域分开，显示出各种组织成分，如复层鳞状上皮、腺组织、神经元、神经胶质、室管膜、纤维肌肉组织、软骨、骨、血管瘤样病变、含黑色素细胞以及一些生殖细胞成分。免疫组织化学研究表明，在一些肿瘤成分中存在S-100蛋白、胶质纤维酸性蛋白（GFAP）、神经元特异性烯醇化酶（NSE）、癌胚抗原（CEA）和因子VIII。特别是，S-100蛋白在一些生殖细胞中的分布提示生殖细胞可能起源于神经外胚层，或者向神经外胚层分化。
