Yamagami T, Handa H, Yamashita J, Okumura T, Paine J, Haebara H, Furukawa F
Acta Neurochir (Wien). 1987;86(1-2):33-41. doi: 10.1007/BF01419502.
Histologically verified intracranial tumours, mainly germ cell tumours of the pineal and suprasellar regions, were studied immunohistochemically using anti-serum of alpha fetoprotein (AFP), human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA), human placental lactogen (HPL), pregnancy specific beta-1 glycoprotein (SP-1), glial fibrillary acidic protein (GFAP), S-100 and neuron specific enolase (NSE). In germinomas, HCG positive cells were occasionally demonstrated in cells presenting as syncytiotrophoblastic giant cells (STGC), and GFAP and S-100 positive cells were found in the surrounding gliotic lesions. Teratomas were positive for CEA in their epithelial components. Endodermal sinus tumours were positive for AFP, choriocarcinomas for HCG and SP-1, and embryonal carcinomas for AFP, HCG and SP-1. HCG and SP-1 positive cells were demonstrated in STGC. As for the relationship between serum AFP level and tissue localization, many cases presenting a serum AFP level exceeding 220 ng/ml were positive for AFP in tumour tissue.
对经组织学证实的颅内肿瘤，主要是松果体区和鞍上区的生殖细胞肿瘤，使用甲胎蛋白（AFP）、人绒毛膜促性腺激素（HCG）、癌胚抗原（CEA）、人胎盘催乳素（HPL）、妊娠特异性β1糖蛋白（SP - 1）、胶质纤维酸性蛋白（GFAP）、S - 100和神经元特异性烯醇化酶（NSE）的抗血清进行免疫组织化学研究。在生殖细胞瘤中，偶尔在表现为合体滋养层巨细胞（STGC）的细胞中发现HCG阳性细胞，并且在周围的胶质增生性病变中发现GFAP和S - 100阳性细胞。畸胎瘤的上皮成分CEA呈阳性。内胚窦瘤AFP呈阳性，绒毛膜癌HCG和SP - 1呈阳性，胚胎癌AFP、HCG和SP - 1呈阳性。在STGC中发现HCG和SP - 1阳性细胞。至于血清AFP水平与组织定位之间的关系，许多血清AFP水平超过220 ng/ml的病例肿瘤组织中AFP呈阳性。
