Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq.
Cell Biochem Biophys. 2024 Sep;82(3):1613-1627. doi: 10.1007/s12013-024-01317-6. Epub 2024 May 28.
The advancement of novel technologies, coupled with bioinformatics, has led to the discovery of additional genes, such as long noncoding RNAs (lncRNAs), that are associated with drug resistance. LncRNAs are composed of over 200 nucleotides and do not possess any protein coding function. These lncRNAs exhibit lower conservation across species, are typically expressed at low levels, and often display high specificity towards specific tissues and developmental stages. The LncRNA MALAT1 plays crucial regulatory roles in various aspects of genome function, encompassing gene transcription, splicing, and epigenetics. Additionally, it is involved in biological processes related to the cell cycle, cell differentiation, development, and pluripotency. Recently, MALAT1 has emerged as a novel mechanism contributing to drug resistance or sensitivity, attracting significant attention in the field of cancer research. This review aims to explore the mechanisms through which MALAT1 confers resistance to chemotherapy and radiotherapy in cancer cells.
新型技术的进步，加上生物信息学，已经发现了其他与耐药性相关的基因，如长非编码 RNA（lncRNA）。lncRNA 由超过 200 个核苷酸组成，不具有任何蛋白质编码功能。这些 lncRNA 在物种间的保守性较低，通常表达水平较低，并且通常对特定组织和发育阶段具有高度特异性。LncRNA MALAT1 在基因组功能的各个方面发挥着关键的调节作用，包括基因转录、剪接和表观遗传学。此外，它还参与与细胞周期、细胞分化、发育和多能性相关的生物学过程。最近，MALAT1 作为一种新的耐药或敏感机制引起了人们的关注，在癌症研究领域引起了广泛关注。本综述旨在探讨 MALAT1 如何赋予癌细胞对化疗和放疗的耐药性的机制。
