Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Pathol Res Pract. 2023 Sep;249:154729. doi: 10.1016/j.prp.2023.154729. Epub 2023 Aug 16.
MicroRNAs (miRNAs) are a widely-studied class of non-coding RNAs characterized by their short length (18-25 nucleotides). The precise functions of miRNAs are not well-elucidated; however, an increasing number of studies suggest their involvement in various physiologic processes and deregulation in pathologic conditions. miRNA-185 (miR-185) is among the mostly-studied miRNAs in human diseases, which is found to play putative roles in conditions like metabolic disorders, asthma, frailty, schizophrenia, and hepatitis. Notably, many cancer studies report the downregulation of miR-185 in cell lines, tumor tissues, and plasma specimens of patients, while it demonstrates a suppressing role on the malignant properties of cancer cells in vitro and in vivo. Accordingly, miR-185 can be considered a tumor suppressor miRNA in human malignancies, while a few studies also report inconsistent findings. Being suggested as a prognostic/diagnostic biomarker, mi-185 is also found to offer clinical potentials, particularly for early diagnosis and prediction of the prognosis of cancer patients. In this review, we have outlined the studies that have evaluated the functions and clinical significance of miR-185 in different human diseases with a particular focus on cancer.
微小 RNA（miRNAs）是一类广泛研究的非编码 RNA，其特征为短长度（18-25 个核苷酸）。miRNAs 的精确功能尚未得到充分阐明；然而，越来越多的研究表明它们参与各种生理过程，并在病理条件下失调。miR-185（miR-185）是人类疾病中研究最多的 miRNAs 之一，据发现其在代谢紊乱、哮喘、脆弱、精神分裂症和肝炎等疾病中发挥着潜在作用。值得注意的是，许多癌症研究报告称，miR-185 在细胞系、肿瘤组织和患者的血浆标本中下调，而在体外和体内抑制癌细胞的恶性特性。因此，miR-185 可以被认为是人类恶性肿瘤中的一种肿瘤抑制 miRNA，而一些研究也报告了不一致的发现。作为一种预后/诊断生物标志物，miR-185 也被发现具有临床潜力，特别是在癌症患者的早期诊断和预后预测方面。在这篇综述中，我们概述了评估 miR-185 在不同人类疾病中的功能和临床意义的研究，特别关注癌症。
