细胞黏附分子埃-钙黏蛋白定位于成年肠上皮细胞的中间连接中。
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.
作者信息
Boller K, Vestweber D, Kemler R
出版信息
J Cell Biol. 1985 Jan;100(1):327-32. doi: 10.1083/jcb.100.1.327.
Abstract
Uvomorulin is a cell-adhesion molecule implicated in the compaction process of mouse preimplantation embryos and the aggregation of embryonal carcinoma cells. A rabbit antiserum against purified uvomorulin also reacts with epithelial cells of various adult tissues. In this study, we investigated the localization of uvomorulin on adult intestinal epithelial cells using electron microscopic analyses. Uvomorulin was shown to exhibit a highly restricted localization in the intermediate junctions of these cells. The results are discussed with respect to a possible adhesive function of uvomorulin on intestinal epithelial cells.
摘要
桥粒芯糖蛋白是一种细胞黏附分子，与小鼠植入前胚胎的致密化过程以及胚胎癌细胞的聚集有关。一种针对纯化桥粒芯糖蛋白的兔抗血清也能与各种成年组织的上皮细胞发生反应。在本研究中，我们利用电子显微镜分析研究了桥粒芯糖蛋白在成年肠上皮细胞上的定位。结果显示桥粒芯糖蛋白在这些细胞的中间连接中呈现高度局限的定位。结合桥粒芯糖蛋白在肠上皮细胞上可能的黏附功能对这些结果进行了讨论。
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