Arab Maliheh, Ashtiani Azadeh Jafari, Faghih Nafiseh, Ghavami Behnaz, Nouri Behnaz, Ardabili Shahla Noori
Department of Gynecology Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Obstetrician and Gynecologist, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2023 Dec;17(4):264-268. doi: 10.18502/jfrh.v17i4.14599.
Malignant transformation in dermoid cysts is rare, and Squamous Cell Carcinoma (SCC) is the most common form. This event often occurs in large tumors and middle-aged women.
In this study, two cases are presented. They were menopause, and abdominal pain and adnexal mass was a common manifestation in both. Case 1 with adenocarcinoma arising in mature cystic teratoma had abnormal tumor markers and was diagnosed with a frozen section during surgery, but case 2 with SCC transformation had normal tumor markers, and the frozen section was not helpful in the first surgery. Both underwent complete staging surgery, and due to stage IC1 in case 1, she received chemotherapy, and in case 2, no adjuvant treatment was needed because of stage IA.
Considering the rarity of malignant transformation in the dermoid cyst, the best surgical approach and adjuvant therapy indications need further research.
皮样囊肿恶变罕见，鳞状细胞癌（SCC）是最常见的形式。这种情况常发生于大肿瘤及中年女性。
本研究呈现两例病例。她们均处于绝经后，腹痛和附件包块是两者的常见表现。病例1为成熟囊性畸胎瘤发生腺癌，肿瘤标志物异常，术中冰冻切片确诊，但病例2为SCC转化，肿瘤标志物正常，首次手术时冰冻切片未提供帮助。两者均接受了全面分期手术，病例1因处于IC1期接受了化疗，病例2因处于IA期无需辅助治疗。
鉴于皮样囊肿恶变罕见，最佳手术方式及辅助治疗指征有待进一步研究。
