Shackelford Rodney E, Mohammad Islam Z, Meram Andrew T, Kim David, Alotaibi Fawaz, Patel Stavan, Ghali Ghali E, Kevil Christopher G
Department of Pathology & Translational Pathobiology, LSU Health Sciences Center Shreveport, Shreveport, LA 71130, USA.
Head & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
Pathophysiology. 2021 Sep 20;28(3):437-456. doi: 10.3390/pathophysiology28030028.
Hydrogen sulfide (HS) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. HS-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, HS promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia-mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased HS-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of HS in cancer, with an emphasis on the molecular mechanisms by which HS promotes cancer development, progression, dedifferentiation, and metastasis.
硫化氢（HS）是一种气体信号分子，在生理和病理生理过程中发挥多种功能。在包括结肠癌、前列腺癌、乳腺癌、肾癌、尿路上皮癌、卵巢癌、口腔鳞状细胞癌和甲状腺癌在内的多种人类恶性肿瘤中，硫化氢合成酶的含量会增加。在癌症中，硫化氢可促进肿瘤生长、细胞和线粒体生物能量代谢、迁移、侵袭、血管生成、肿瘤血流、转移、上皮-间质转化、DNA修复、蛋白质巯基化以及化疗耐药性。此外，在某些恶性肿瘤中，硫化氢合成酶表达的增加与较差的预后和较高的肿瘤分期相关。在此，我们综述了硫化氢在癌症中的作用，重点关注硫化氢促进癌症发生、发展、去分化和转移的分子机制。
