CD10标记物在鉴别结直肠癌与腺瘤性息肉中的诊断意义：一项病理相关性研究。

Diagnostic significance of CD10 marker to differentiate colorectal adenocarcinoma from adenomatous polyp: A pathological correlation.

作者信息

Dehini Ghasem, Ghorbani Hossein, Khafri Soraya, Shokri Shirvani Javad, Hosseini Akramossadat, Sadr Mohararpur Sahar, Rouhi Tina

机构信息

Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.

Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

出版信息

Caspian J Intern Med. 2024 Spring;15(2):228-233. doi: 10.22088/cjim.15.2.228.

DOI:10.22088/cjim.15.2.228

PMID:38807719

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11129067/

Abstract

BACKGROUND

Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps.

METHODS

This cross-sectional study was conducted on 141 patients with colorectal adenocarcinoma and adenomatous polyps referred to Ayatollah Rouhani Hospital from March 2020 to March 2021. Differential diagnoses of colorectal adenocarcinoma and adenomatous polyps were made colonoscopically, and then samples were taken from the lesions. The pathologists confirmed the final diagnosis as colorectal adenocarcinoma, high-grade or low-grade adenomatous polyps. The stromal and epithelial CD10 expression was evaluated by immunohistochemistry. The data was analyzed by SPSS 22 software (p<0.05).

RESULTS

Sixty-five (46.1%) of the cases were low-grade polyps that were included positive (4 cases; 6.20%) and negative (61 cases; 93.80%) CD10 expression (P=0.001), also 76 (53.9%) of them were either high-grade polyps (21 cases) or adenocarcinomas (21 cases). Also, epithelial CD10 expression was significantly higher in the well-differentiated adenocarcinoma (38 cases) group than moderate (13 cases) and poor (4 cases) groups (P =0.001). Moreover, the CD10 expression level in the adenomatous polyps (10 positive cases and 76 negative cases) was correlated with the degree of dysplasia (P = 0.001) and the presence of tumor invasion (8 positive cases and 133 negative cases) (P = 0.001).

CONCLUSION

The CD10 expression is associated with an increased degree of dysplasia and the presence of tumor invasion in patients with pre-neoplastic lesions and colorectal adenocarcinoma.

摘要

背景

结直肠癌可能由腺瘤性息肉发展而来。本研究旨在评估基质和上皮CD10（中性肽链内切酶）表达在结直肠癌和腺瘤性息肉患者中的诊断意义。

方法

本横断面研究于2020年3月至2021年3月对141例转诊至阿亚图拉·鲁哈尼医院的结直肠癌和腺瘤性息肉患者进行。通过结肠镜检查对结直肠癌和腺瘤性息肉进行鉴别诊断，然后从病变处取样。病理学家将最终诊断确认为结直肠癌、高级别或低级别腺瘤性息肉。通过免疫组织化学评估基质和上皮CD10表达。数据采用SPSS 22软件进行分析（p<0.05）。

结果

65例（46.1%）病例为低级别息肉，其中CD10表达阳性（4例；6.20%）和阴性（61例；93.80%）（P=0.001），另外76例（53.9%）为高级别息肉（21例）或腺癌（21例）。此外，高分化腺癌（38例）组上皮CD10表达明显高于中分化（13例）和低分化（4例）组（P =0.001）。此外，腺瘤性息肉（10例阳性和76例阴性）中CD10表达水平与发育异常程度（P =0.001）和肿瘤浸润情况（8例阳性和133例阴性）（P =0.001）相关。