Lishner M, Lang R, Kedar I, Ravid M
J Am Geriatr Soc. 1985 Jan;33(1):41-3. doi: 10.1111/j.1532-5415.1985.tb02858.x.
Perforating foot ulcers constitute a major problem in diabetics with peripheral neuropathy for which no specific therapy is available. Twenty patients with chronic, resistant mal perforant were treated by local application of dimethylsulfoxide (DMSO) solution. Complete healing of the ulcers was achieved in 14 patients following 4-15 weeks of daily treatment. Partial resolution was observed in another four patients, and in the remaining two there was no effect. A control group, equal in number, was treated conventionally. Complete healing of the ulcers took place in only two patients. The therapeutic effect of DMSO most probably results from an increase in tissue oxygen saturation via a combined mechanism of local vasodilatation, decreased thrombocyte aggregation, and increased oxygen diffusion. Local DMSO is effective, simple, devoid of systemic side effects, and inexpensive. It should be employed for diabetic foot ulcers prior to the consideration of surgical measures.
足部穿孔性溃疡是糖尿病合并周围神经病变患者面临的一个主要问题，目前尚无特效治疗方法。20例慢性、难治性足部溃疡患者接受了局部应用二甲亚砜（DMSO）溶液的治疗。经过4至15周的每日治疗，14例患者的溃疡完全愈合。另外4例患者溃疡部分愈合，其余2例患者无效。设立了一个数量相同的对照组，采用传统方法治疗。溃疡完全愈合的仅2例。DMSO的治疗效果很可能是通过局部血管扩张、血小板聚集减少和氧扩散增加的联合机制，使组织氧饱和度升高而产生的。局部应用DMSO有效、简单、无全身副作用且价格低廉。在考虑手术治疗之前，应将其用于糖尿病足溃疡的治疗。
