He Wen-Rui, Yuan Jin, Ma Yu-He, Zhao Cheng-Yan, Yang Zhong-Yuan, Zhang Yuhang, Han Shichong, Wan Bo, Zhang Gai-Ping
International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.
Animals (Basel). 2022 Oct 26;12(21):2935. doi: 10.3390/ani12212935.
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and fatal disease found in swine. However, the viral proteins and mechanisms responsible for immune evasion are poorly understood, which has severely hindered the development of vaccines. This review mainly focuses on studies involving the innate antiviral immune response of the host and summarizes the latest studies on ASFV genes involved in interferon (IFN) signaling and inflammatory responses. We analyzed the effects of candidate viral proteins on ASFV infection, replication and pathogenicity and identified potential molecular targets for novel ASFV vaccines. These efforts will contribute to the construction of novel vaccines and wonder therapeutics for ASF.
非洲猪瘟（ASF）由非洲猪瘟病毒（ASFV）引起，是一种在猪身上发现的高度传染性和致命性疾病。然而，人们对负责免疫逃避的病毒蛋白和机制了解甚少，这严重阻碍了疫苗的研发。本综述主要关注涉及宿主先天性抗病毒免疫反应的研究，并总结了关于ASFV基因参与干扰素（IFN）信号传导和炎症反应的最新研究。我们分析了候选病毒蛋白对ASFV感染、复制和致病性的影响，并确定了新型ASFV疫苗的潜在分子靶点。这些努力将有助于构建针对ASF的新型疫苗和奇妙疗法。
