Department of Dermatology and Venereology, Ankara Etlik City Hospital, Ankara, Turkey.
Indian J Pharmacol. 2024 Mar 1;56(2):141-143. doi: 10.4103/ijp.ijp_743_23. Epub 2024 Apr 30.
Nicolau syndrome (NS) is a rare and unpredictable adverse reaction that can occur after the administration of certain medications. A 9-year-old girl, accompanied by her father, visited the outpatient dermatology clinic with complaints of wounds on both upper arms. Upon reviewing her medical history, it was discovered that she had been receiving leuprolide for precocious puberty, and the symptoms began after the last two injections. The patient experienced pain during the leuprolide injection, and redness and swelling were noticed in the injection area on the same day. A few days later, the redness turned into ulcers. The fact that the development of NS cannot be detected in advance and the risk of rapid progression of tissue necrosis make disease management difficult. The prognosis of NS significantly depends on the patient, and when a developing lesion is noticed early, it is crucial to minimize the risk of complications.
尼科劳综合征（Nicolau syndrome，NS）是一种罕见且不可预测的药物不良反应，可在使用某些药物后发生。一位 9 岁女孩在父亲的陪同下，因双上臂伤口就诊于皮肤科门诊。查阅其病历，发现她因性早熟正在接受亮丙瑞林治疗，且症状出现在最后两次注射后。患者在亮丙瑞林注射时感到疼痛，当天在注射部位发现红肿。几天后，红肿变成了溃疡。NS 的发生无法提前检测，组织坏死的风险迅速进展，这使得疾病管理变得困难。NS 的预后显著取决于患者，当发现正在发展的病变时，早期最小化并发症的风险至关重要。
