Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, Gulu, Uganda.
Department of Internal Medicine, Gulu Regional Referral Hospital, Gulu, Uganda.
Transpl Infect Dis. 2024 Jun;26(3):e14300. doi: 10.1111/tid.14300. Epub 2024 May 29.
HIV+-to-HIV+ organ transplantation has demonstrated promise and is now authorized for research purposes in certain countries. However, organ transplantation is dependent on the availability of organ donors. We assessed the awareness and willingness to donate organs among people with HIV (PWH) in Uganda.
We conducted a multicenter cross-sectional study between October 2023 and January 2024 in four large HIV clinics in Northern Uganda. The study population consisted of PWH. A structured questionnaire was used to collect data regarding awareness, willingness, and beliefs regarding organ donation. Organ donation was defined as the willingness to be a living donor of a solid organ. We conducted multivariable logistic regression to assess for an association between willingness to donate organs and selected exposures. Data were analyzed in Stata version 15.0. Results are expressed as adjusted odds ratio (AOR) with 95% confidence intervals (CI).
A total of 232 participants were recruited. The mean age ± standard deviation of the participants was 42.2±11.8 years. All participants were on antiretroviral therapy. Sixty-two (26.7%) had a CD4 count less than or equal to 200 cells/mm. The majority (80.6%, n = 187) had ever heard of organ donation. Slightly more than a third (34.9%, n = 81) were willing to donate organs. Factors associated with willingness to be a living organ donor included being female (AOR: 1.56; 95% CI: 1.15-2.11), having a tertiary education level (AOR: 1.79; 95% CI: 1.03-3.11), average monthly income >500 000 UGX (135.1USD) (AOR: 5.5; 95% CI: 1.97-15.40), ever heard about organ donation (AOR: 5.4; 95% CI: 1.67-17.8), and attending an organ donation campaign (AOR: 2.0; 95% CI: 1.07-3.74).
Awareness about organ donation was high but the willingness to be a living organ donor was low among PWH in Uganda. There is a need to sensitize the community about the need and benefits of organ donation with the involvement of media and the healthcare workers.
HIV+ 到 HIV+ 的器官移植已被证明有前景，现在某些国家已授权出于研究目的进行该手术。然而，器官移植依赖于器官供体的可用性。我们评估了乌干达 HIV 感染者（PWH）对器官捐献的认知和意愿。
我们于 2023 年 10 月至 2024 年 1 月在乌干达北部的四个大型 HIV 诊所进行了一项多中心横断面研究。研究人群由 PWH 组成。使用结构化问卷收集有关器官捐献认知、意愿和信念的数据。器官捐献定义为愿意成为实体器官的活体捐献者。我们进行了多变量逻辑回归分析，以评估愿意捐献器官与选定暴露因素之间的关联。数据在 Stata 版本 15.0 中进行分析。结果表示为调整后的优势比（AOR）和 95%置信区间（CI）。
共招募了 232 名参与者。参与者的平均年龄 ± 标准差为 42.2±11.8 岁。所有参与者均接受抗逆转录病毒治疗。62 名（26.7%）的 CD4 计数小于或等于 200 个细胞/mm³。大多数（80.6%，n=187）听说过器官捐献。略超过三分之一（34.9%，n=81）愿意捐献器官。愿意成为活体器官捐献者的因素包括女性（AOR：1.56；95%CI：1.15-2.11）、具有高等教育水平（AOR：1.79；95%CI：1.03-3.11）、月收入高于 500000 乌干达先令（135.1 美元）（AOR：5.5；95%CI：1.97-15.40）、听说过器官捐献（AOR：5.4；95%CI：1.67-17.8）和参加器官捐献活动（AOR：2.0；95%CI：1.07-3.74）。
乌干达 PWH 对器官捐献的认知度较高，但愿意成为活体器官捐献者的意愿较低。需要通过媒体和医疗保健工作者的参与，提高社区对器官捐献必要性和益处的认识。
