Chulalongkorn Center of Excellence for Parkinson's Disease & Related Disorders, King Chulalongkorn Memorial Hospital, The Thai Red Cross, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Curr Opin Neurol. 2024 Aug 1;37(4):414-420. doi: 10.1097/WCO.0000000000001286. Epub 2024 May 29.
This review aimed to comprehensively outline sleep and circadian rhythm abnormalities in hyperkinetic movement disorders beyond Parkinson's disease and atypical parkinsonisms, including tremor, dystonia, choreiform movements, tics, and ataxia disorders.
Insomnia, poor sleep quality, and excessive daytime sleepiness (EDS) are commonly reported in essential tremor, Wilson's disease, tics or Tourette's syndrome, and spinocerebellar ataxia (SCA). REM sleep behavior disorder (RBD) have been observed in Wilson's disease and SCA. A combination of REM and non-REM parasomnias, along with nocturnal stridor with the initiation of sleep and re-entering after awakening, are characterized by undifferentiated Non-REM and poorly structured N2 in anti-IgLON5 disease. Restless legs syndrome (RLS) has been reported commonly in SCAs. Sleep-related dyskinesia has been reported in ADCY5-related disease and GNAO1-related movement disorder.
Sleep problems can manifest as a result of movement disorders, either through direct motor disturbances or secondary nonmotor symptoms. Medication effects must be considered, as certain medications for movement disorders can exacerbate or alleviate sleep disturbances. Distinguishing sleep problems in some diseases might involve pathognomonic symptoms and signs, aiding in the diagnosis of movement disorders.
本文旨在全面概述除帕金森病和非典型性帕金森病之外的其他运动障碍性疾病中的睡眠和昼夜节律紊乱，包括震颤、肌张力障碍、舞蹈症、妥瑞氏症和共济失调。
特发性震颤、威尔逊病、妥瑞氏症或抽动秽语综合征和脊髓小脑共济失调（SCA）中常出现失眠、睡眠质量差和日间嗜睡（EDS）。Wilson 病和 SCA 中观察到 REM 睡眠行为障碍（RBD）。抗 IgLON5 病的特征是非 REM 和结构不佳的 N2 的 REM 和非 REM 共发性睡眠障碍以及睡眠起始和唤醒后再次出现的夜间喘鸣。SCAs 中常出现不安腿综合征（RLS）。ADCY5 相关疾病和 GNAO1 相关运动障碍中出现与睡眠相关的运动障碍。
睡眠问题可能是运动障碍的结果，要么是由于直接的运动障碍，要么是由于继发的非运动症状。必须考虑药物的影响，因为某些运动障碍的药物可能会加重或减轻睡眠障碍。在某些疾病中，区分睡眠问题可能涉及特征性症状和体征，有助于运动障碍的诊断。
