Cinotti A, Cinotti D, Grant W, Jacobs I, Galin M, Silverstone D, Shin D, Esters J, Lee J, Bouchey R
Am J Ophthalmol. 1985 Jan 15;99(1):11-7. doi: 10.1016/s0002-9394(14)75859-3.
A group of 162 patients with chronic open-angle glaucoma or ocular hypertension were treated twice daily for up to 15 months with one of the following topical ophthalmic solutions: 0.5% levobunolol, 1% levobunolol, or 0.5% timolol. Overall mean reductions in intraocular pressure were 8 mm Hg for patients receiving 0.5% levobunolol or timolol and 8.2 mm Hg for patients receiving 1% levobunolol. There were no significant differences between levobunolol and timolol in mean reductions in intraocular pressure, percent of patients with adequately controlled intraocular pressure, or life-table estimates of the probability of successful treatment.
一组162例慢性开角型青光眼或高眼压症患者，每天使用以下一种局部眼科溶液治疗两次，持续长达15个月：0.5%左布诺洛尔、1%左布诺洛尔或0.5%噻吗洛尔。接受0.5%左布诺洛尔或噻吗洛尔治疗的患者眼压总体平均降低8 mmHg，接受1%左布诺洛尔治疗的患者眼压总体平均降低8.2 mmHg。左布诺洛尔和噻吗洛尔在眼压平均降低值、眼压得到充分控制的患者百分比或成功治疗概率的生命表估计方面无显著差异。
