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迈向人工肽纳米胶囊。

Toward Artificial Peptide Nanocapsules.

作者信息

Wang Yuan, Chen Bing

机构信息

Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

College of Electronic and Optical Engineering and College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing, 210023, People's Republic of China.

出版信息

Nanomicro Lett. 2024 May 29;16(1):204. doi: 10.1007/s40820-024-01443-z.

DOI:10.1007/s40820-024-01443-z
PMID:38811461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11136888/
Abstract

The formation of peptide nanocapsules is facilitated by a gradient interface, where the differential solvent concentration drives the peptides to preferentially localize and assemble. The peptide nanocapsules, characterized by their hollow structures, demonstrated potential as carriers for targeted drug delivery.

摘要

肽纳米胶囊的形成由梯度界面促进,其中不同的溶剂浓度驱使肽优先定位并组装。以中空结构为特征的肽纳米胶囊展现出作为靶向药物递送载体的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc2/11136888/bba35c696ad5/40820_2024_1443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc2/11136888/bba35c696ad5/40820_2024_1443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc2/11136888/bba35c696ad5/40820_2024_1443_Fig1_HTML.jpg

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本文引用的文献

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Self-assembly of peptide nanocapsules by a solvent concentration gradient.溶剂浓度梯度自组装肽纳米胶囊。
Nat Nanotechnol. 2024 Aug;19(8):1141-1149. doi: 10.1038/s41565-024-01654-w. Epub 2024 Apr 26.
2
Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders.用于高效细胞溶质蛋白递送和炎症性皮肤疾病的 CRISPR-Cas9 基因治疗的双响应性纳米载体。
Sci Adv. 2024 Apr 19;10(16):eadl4336. doi: 10.1126/sciadv.adl4336. Epub 2024 Apr 17.
3
Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy.
用于癌症治疗的刺激响应性基因递送纳米载体
Nanomicro Lett. 2023 Feb 8;15(1):44. doi: 10.1007/s40820-023-01018-4.
4
Multifunctional biomolecule nanostructures for cancer therapy.用于癌症治疗的多功能生物分子纳米结构。
Nat Rev Mater. 2021;6(9):766-783. doi: 10.1038/s41578-021-00315-x. Epub 2021 May 19.