用于癌症靶向递送的超顺磁性人工细胞PLGA-FeO微/纳米胶囊
Superparamagnetic Artificial Cells PLGA-FeO Micro/Nanocapsules for Cancer Targeted Delivery.
作者信息
Wang Tao, Chang Thomas Ming Swi
机构信息
Artificial Cells and Organs Research Centre, Departments of Medicine and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, QC H3G 1Y6, Canada.
出版信息
Cancers (Basel). 2023 Dec 12;15(24):5807. doi: 10.3390/cancers15245807.
Artificial cells have been extensively used in many fields, such as nanomedicine, biotherapy, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, and the COVID-19 vaccine. The unique properties of superparamagnetic FeO nanoparticles have contributed to increased interest in using superparamagnetic artificial cells (PLGA-FeO micro/nanocapsules) for targeted therapy. In this review, the preparation methods of FeO NPs and superparamagnetic artificial cell PLGA-drug-FeO micro/nanocapsules are discussed. This review also focuses on the recent progress of superparamagnetic PLGA-drug-FeO micro/nanocapsules as targeted therapeutics. We shall concentrate on the use of superparamagnetic artificial cells in the form of PLGA-drug-FeO nanocapsules for magnetic hyperthermia/photothermal therapy and cancer therapies, including lung breast cancer and glioblastoma.
人工细胞已广泛应用于许多领域，如纳米医学、生物疗法、血液替代品、药物递送、酶/基因治疗、癌症治疗以及新冠疫苗。超顺磁性FeO纳米颗粒的独特性质促使人们对使用超顺磁性人工细胞（PLGA-FeO微/纳米胶囊）进行靶向治疗的兴趣日益增加。在本综述中，讨论了FeO纳米颗粒和超顺磁性人工细胞PLGA-药物-FeO微/纳米胶囊的制备方法。本综述还聚焦于超顺磁性PLGA-药物-FeO微/纳米胶囊作为靶向治疗药物的最新进展。我们将专注于以PLGA-药物-FeO纳米胶囊形式的超顺磁性人工细胞在磁热疗/光热疗法以及包括肺癌、乳腺癌和胶质母细胞瘤在内的癌症治疗中的应用。
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