Zhongguo Zhong Yao Za Zhi. 2024 May;49(9):2544-2556. doi: 10.19540/j.cnki.cjcmm.20240130.501.
Recurrent spontaneous abortion is one of the most common pregnancy complications in obstetrics and gynecology. The normative diagnosis and treatment of recurrent spontaneous abortion has become an important problem to be solved urgently in the field of reproductive health. The integrated traditional Chinese and western medicine provides a safe and effective treatment method for recurrent spontaneous abortion, but there is no guideline for diagnosis and treatment of recurrent spontaneous abortion with integrated traditional Chinese and western medicine. The guideline is based on the requirements of World Health Organization(WHO) handbook for guideline development and follows the principles of evidence-based medicine. Through literature pre-search, expert interviews, clinical research, and conference consensus, 16 clinical problems are identified in this guideline. PICO principles are used for evidence retrieval, screening, and synthesis. The evidence quality is evaluated for the included evidence bodies. Recommendation opinions and consensus suggestions are formed through three rounds of the Delphi expert questionnaire survey. An expert meeting is held to finalize the draft. The opinions of experts in traditional Chinese medicine, western medicine, integrated traditional Chinese and western medicine, methodology and pharmacy are widely solicited. The guideline contains five parts: scope, term and definition, diagnosis, treatment, and diagnosis and treatment flow chart of integrated traditional Chinese and western medicine. There are corresponding recommendations and summaries of evidence for clinical problems related to the diagnosis and treatment of integrated traditional Chinese and western medicine. This guideline is guided by clinical problems, combining disease differentiation and syndrome differentiation and integrating pre-pregnancy regulation and treatment and post-pregnancy preservation, highlighting the therapeutic advantages of integrated traditional Chinese and western medicine, so as to further standardize the clinical diagnosis and treatment of recurrent spontaneous abortion and promote the diagnosis and treatment level of integrated traditional Chinese and western medicine for recurrent spontaneous abortion.
复发性自然流产是妇产科最常见的妊娠并发症之一。复发性自然流产的规范诊治已成为生殖健康领域亟待解决的重要问题。中西医结合为复发性自然流产提供了安全有效的治疗方法，但目前尚无中西医结合诊治复发性自然流产的指南。本指南依据世界卫生组织（WHO）指南制定手册的要求，遵循循证医学原则。通过文献预检索、专家访谈、临床研究及会议共识，本指南确定了16个临床问题。采用PICO原则进行证据检索、筛选及合成。对纳入的证据体进行证据质量评价。通过三轮德尔菲专家问卷调查形成推荐意见和共识建议。召开专家会议确定草案。广泛征求中医、西医、中西医结合、方法学及药学等方面专家的意见。本指南共包括范围、术语与定义、诊断、治疗以及中西医结合诊治流程图五个部分。针对中西医结合诊治相关临床问题有相应的推荐意见及证据总结。本指南以临床问题为导向，病证结合，孕前调治与孕后安胎相结合，突出中西医结合的治疗优势，以进一步规范复发性自然流产的临床诊治，提高中西医结合诊治复发性自然流产的水平。
