Rojas José M, Sevilla Noemí, Martín Verónica
Centro de Investigación en Sanidad Animal (CISA-INIA-CSIC), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Front Vet Sci. 2021 Sep 8;8:729879. doi: 10.3389/fvets.2021.729879. eCollection 2021.
Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep causing significant economic loss in Africa and Asia, but also posing a serious threat to Europe, as recent outbreaks in Georgia (2016) and Bulgaria (2018) have been reported. In order to carry out the eradication of PPRV, an objective set for 2030 by the Office International des Epizooties (OIE) and the Food and Agriculture Organization of the United Nations (FAO), close collaboration between governments, pharmaceutical companies, farmers and researchers, among others, is needed. Today, more than ever, as seen in the response to the SARS-CoV2 pandemic that we are currently experiencing, these goals are feasible. We summarize in this review the current vaccination approaches against PPRV in the field, discussing their advantages and shortfalls, as well as the development and generation of new vaccination strategies, focusing on the potential use of adenovirus as vaccine platform against PPRV and more broadly against other ruminant pathogens.
小反刍兽疫病毒（PPRV）是一种主要感染山羊和绵羊的病毒，在非洲和亚洲造成了重大经济损失，同时也对欧洲构成了严重威胁，如近期格鲁吉亚（2016年）和保加利亚（2018年）都报告了疫情爆发。为了实现国际兽疫局（OIE）和联合国粮食及农业组织（FAO）设定的2030年根除PPRV的目标，政府、制药公司、农民和研究人员等各方需要密切合作。如今，正如我们在应对当前的SARS-CoV2大流行中所看到的，这些目标比以往任何时候都更可行。在本综述中，我们总结了目前针对PPRV的现场疫苗接种方法，讨论了它们的优缺点，以及新疫苗策略的开发和产生，重点关注腺病毒作为针对PPRV以及更广泛地针对其他反刍动物病原体的疫苗平台的潜在用途。
