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2019冠状病毒病大流行对动脉高血压和冠心病住院率的影响:一项德国数据库研究

Impact of the COVID-19 pandemic on hospital admission rates for arterial hypertension and coronary heart disease: a German database study.

作者信息

Sasko Benjamin, Matiakis Marios, Seibert Felix S, Pagonas Nikolaos, Hippe Hans-Jörg, Babel Nina, Ukena Christian, Westhoff Timm H

机构信息

Medical Department II, Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.

Medical Department I, Marien Hospital Herne, Ruhr-University of Bochum, Herne, Germany.

出版信息

Front Cardiovasc Med. 2024 May 14;11:1333749. doi: 10.3389/fcvm.2024.1333749. eCollection 2024.

Abstract

BACKGROUND

During the SARS-CoV-2 pandemic it was speculated that the virus might be associated with a persistent increase of cardiovascular risk. The present study compares pre- and post-pandemic hospital admission rates for hypertension and coronary artery disease.

METHODS

Systematic multicentric retrospective cohort analysis of 57.795 hospital admissions in an urban region in Germany during two different periods (pre-pandemic 01-06/2019 vs. post-pandemic era 01-06/2023). Information on hospital admissions for arterial hypertension, chronic coronary syndrome, unstable angina pectoris and acute myocardial infarction were extracted from the hospitals data systems. Additionally, six comorbidities and performed coronary interventions were monitored.

RESULTS

Compared to the pre-pandemic era, there was no increase in hospitalizations for arterial hypertension (516 vs. 483, -6.8%,  = 0.07) or myocardial infarction (487 vs. 349, -23.8%,  < 0.001), but the total number of patient admissions with chest pain as the presenting symptom increased (chronic coronary syndrome: 759 vs. 943, +24.2%,  < 0.001; unstable angina pectoris: 270 vs. 451, +67.0%,  < 0.001). At the same time, the number of performed coronary angiographies increased, but less patients underwent percutaneous interventions. Patients admitted with chest pain in the post-pandemic era were in general healthier with less comorbidities.

CONCLUSION

The present multicenter cohort study found no evidence for an increase in hospitalizations for arterial hypertension or coronary artery disease after the end of the pandemic. However, further studies with larger sample sizes are needed to confirm our results.

摘要

背景

在新冠病毒大流行期间,有人推测该病毒可能与心血管疾病风险的持续增加有关。本研究比较了大流行前后高血压和冠状动脉疾病的住院率。

方法

对德国一个城市地区在两个不同时期(大流行前:2019年1月至6月;大流行后时期:2023年1月至6月)的57795例住院病例进行系统的多中心回顾性队列分析。从医院数据系统中提取有关动脉高血压、慢性冠状动脉综合征、不稳定型心绞痛和急性心肌梗死住院的信息。此外,还监测了六种合并症和进行的冠状动脉介入治疗。

结果

与大流行前时期相比,动脉高血压住院人数没有增加(516例对483例,-6.8%,P = 0.07)或心肌梗死住院人数没有增加(487例对349例,-23.8%,P < 0.001),但以胸痛为主要症状的患者住院总数增加了(慢性冠状动脉综合征:759例对943例,+24.2%,P < 0.001;不稳定型心绞痛:270例对451例,+67.0%,P < 0.001)。同时,冠状动脉造影的数量增加了,但接受经皮介入治疗的患者减少了。大流行后时期因胸痛入院的患者总体上更健康,合并症更少。

结论

本多中心队列研究没有发现大流行结束后动脉高血压或冠状动脉疾病住院人数增加的证据。然而,需要进一步的大样本研究来证实我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b250/11135167/b3887c26e840/fcvm-11-1333749-g001.jpg

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