Qiu Shanru, Dai Hui, Wang Yu, Lv Yehua, Yu Bin, Yao Chun
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
Front Cell Neurosci. 2024 May 15;18:1404463. doi: 10.3389/fncel.2024.1404463. eCollection 2024.
Spinal cord injury (SCI) can cause loss of sensory and motor function below the level of injury, posing a serious threat to human health and quality of life. One significant characteristic feature of pathological changes following injury in the nervous system is demyelination, which partially contributes to the long-term deficits in neural function after injury. The remyelination in the central nervous system (CNS) is mainly mediated by oligodendrocyte progenitor cells (OPCs). Numerous complex intracellular signaling and transcriptional factors regulate the differentiation process from OPCs to mature oligodendrocytes (OLs) and myelination. Studies have shown the importance of microRNA (miRNA) in regulating OPC functions. In this review, we focus on the demyelination and remyelination after SCI, and summarize the progress of miRNAs on OPC functions and remyelination, which might provide a potential therapeutic target for SCI treatments.
脊髓损伤（SCI）可导致损伤平面以下感觉和运动功能丧失，对人类健康和生活质量构成严重威胁。神经系统损伤后病理变化的一个显著特征是脱髓鞘，这在一定程度上导致了损伤后神经功能的长期缺陷。中枢神经系统（CNS）中的髓鞘再生主要由少突胶质前体细胞（OPCs）介导。众多复杂的细胞内信号传导和转录因子调节着OPCs向成熟少突胶质细胞（OLs）的分化过程以及髓鞘形成。研究表明，微小RNA（miRNA）在调节OPC功能方面具有重要作用。在本综述中，我们聚焦于SCI后的脱髓鞘和髓鞘再生，并总结miRNA在OPC功能和髓鞘再生方面的研究进展，这可能为SCI治疗提供一个潜在的治疗靶点。
