Xu Jiahui, Sun Zhaoqing, Zhang Rui, Li Ruixue, Yu Zhecong, Zhang Qianlong, Ma Yanan, Xing Fuguo, Zheng Liqiang
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Aging Neurosci. 2022 Aug 2;14:924984. doi: 10.3389/fnagi.2022.924984. eCollection 2022.
Although animal studies show that spermidine (SPD) affects cognitive function, the relevant evidence among humans is limited. We aim to examine the association between serum SPD levels and cognitive performance.
We conducted a cross-sectional and longitudinal study including a baseline and one follow-up survey. The baseline survey was conducted from June 2019 to August 2019, while the follow-up survey was conducted from June 2021 to August 2021. We analyzed 3,774 adult participants aged >35 years, who had no history of dementia.
The mean (SD) age of the participants was 57.4 (9.8) years. Relative to the first tertile, the multivariate-adjusted ORs (95% CIs) of mild cognitive impairment (MCI) for the second and third tertile groups were 0.78 (0.65, 0.93) and 0.80 (0.67, 0.96), respectively. Restricted cubic spline models show that there is a non-linear association between SPD and MCI. In line with cross-sectional findings, the longitudinal study showed that a high SPD concentration may indicate a lower risk of MCI [ORs (95% CIs) for the third tertile of 0.62 (0.39, 0.99)].
Our findings suggest that SPD is favorable for cognitive function. Monitoring the SPD levels may help reduce the incidence of MCI, hence decreasing the burden of MCI.
尽管动物研究表明亚精胺（SPD）会影响认知功能，但人类中的相关证据有限。我们旨在研究血清SPD水平与认知表现之间的关联。
我们进行了一项横断面和纵向研究，包括一次基线调查和一次随访调查。基线调查于2019年6月至2019年8月进行，随访调查于2021年6月至2021年8月进行。我们分析了3774名年龄大于35岁且无痴呆病史的成年参与者。
参与者的平均（标准差）年龄为57.4（9.8）岁。相对于第一三分位数，第二和第三三分位数组轻度认知障碍（MCI）的多变量调整OR（95%CI）分别为0.78（0.65，0.93）和0.80（0.67，0.96）。受限立方样条模型显示SPD与MCI之间存在非线性关联。与横断面研究结果一致，纵向研究表明，高SPD浓度可能表明MCI风险较低[第三三分位数的OR（95%CI）为0.62（0.39，0.99）]。
我们的研究结果表明SPD对认知功能有益。监测SPD水平可能有助于降低MCI的发病率，从而减轻MCI的负担。
