长链非编码 RNA 在胰腺癌中的作用：从生物标志物到治疗靶点。
Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets.
机构信息
Department of Molecular Biology and Genetics, Hamidiye Institute of Health Sciences, University of Health Sciences, İstanbul, Turkiye.
Experimental Medicine Research and Application Center, University of Health Sciences, İstanbul, Turkiye.
出版信息
Turk J Med Sci. 2023 Sep 9;53(6):1552-1564. doi: 10.55730/1300-0144.5724. eCollection 2023.
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.
长链非编码 RNA（lncRNA）是一类具有异质结构的非编码 RNA 分子，由 200 个或更多的核苷酸组成。由于这些非编码 RNA 是由 RNA 聚合酶 II 转录的，因此它们具有类似于信使 RNA（mRNA）的性质。与普遍的看法相反，“ncRNA”一词是在发现 microRNA 之前出现的。lncRNA 基因的数量多于编码蛋白质的基因。由于它们在癌症相关过程（如细胞增殖、分化和迁移）中起着关键作用，因此它们是当前分子研究的重点。全球范围内胰腺癌（PC）的发病率正在上升，对 PC 分子方面的研究也在不断增加。在这篇综述中，旨在提供关于 PC 中 lncRNA 的关键信息，包括 lncRNA 在 PC 中的生物学和肿瘤学行为及其在治疗策略和作为诊断肿瘤标志物中的潜在应用。
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