解码 mRNA 疫苗研究趋势：一项全面的文献计量学研究。

BACKGROUND: In recent years, infectious diseases like COVID-19 have had profound global socio-economic impacts. mRNA vaccines have gained prominence due to their rapid development, industrial adaptability, simplicity, and responsiveness to new variants. Notably, the 2023 Nobel Prize in Physiology or Medicine recognized significant contributions to mRNA vaccine research. METHODS: Our study employed a comprehensive bibliometric analysis using the Web of Science Core Collection (WoSCC) database, encompassing 5,512 papers on mRNA vaccines from 2003 to 2023. We generated cooperation maps, co-citation analyses, and keyword clustering to evaluate the field's developmental history and achievements. RESULTS: The analysis yielded knowledge maps highlighting countries/institutions, influential authors, frequently published and highly cited journals, and seminal references. Ongoing research hotspots encompass immune responses, stability enhancement, applications in cancer prevention and treatment, and combating infectious diseases using mRNA technology. CONCLUSIONS: mRNA vaccines represent a transformative development in infectious disease prevention. This study provides insights into the field's growth and identifies key research priorities, facilitating advancements in vaccine technology and addressing future challenges.

背景：近年来，COVID-19 等传染病对全球社会经济产生了深远影响。mRNA 疫苗因其快速发展、工业适应性强、操作简单以及能够针对新变体迅速做出反应而备受关注。值得注意的是，2023 年诺贝尔生理学或医学奖表彰了在 mRNA 疫苗研究方面的重大贡献。

方法：我们使用 Web of Science Core Collection（WoSCC）数据库进行了全面的文献计量分析，其中包含了 2003 年至 2023 年关于 mRNA 疫苗的 5512 篇论文。我们生成了合作图谱、共被引分析和关键词聚类，以评估该领域的发展历史和成就。

结果：分析结果生成了知识图谱，突出显示了国家/机构、有影响力的作者、经常发表和高引用的期刊以及开创性的参考文献。当前的研究热点包括免疫反应、稳定性增强、在癌症预防和治疗中的应用，以及使用 mRNA 技术防治传染病。

结论：mRNA 疫苗是预防传染病的一项重大突破。本研究深入了解了该领域的发展，并确定了关键的研究重点，为疫苗技术的进步和应对未来的挑战提供了帮助。