Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yunlin, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
J Microbiol Immunol Infect. 2024 Oct;57(5):739-748. doi: 10.1016/j.jmii.2024.05.006. Epub 2024 May 24.
Male hypogonadism is not uncommon in people with HIV (PWH), with estimated prevalence ranging from 9% to 16%. Existing data are limited on the serum testosterone levels in PWH in Asian populations.
We enrolled HIV-positive men who have sex with men (MSM) and had been on stable antiretroviral therapy and MSM without HIV between February 2021 and November 2022. Serum free testosterone levels, sex hormone-binding globulins and other associated hormones were measured. Multiple linear regression analysis was performed to assess the association between serum free testosterone levels and clinical variables collected.
A total of 447 MSM with HIV and 124 MSM without HIV were enrolled. Compared with MSM without HIV, MSM with HIV had a higher age (median, 41 versus 29.5 years) and prevalence of symptomatic hypogonadism (8.3% versus 1.6%). Among MSM who were aged <35 years, there were no significant differences in the serum free testosterone levels and prevalences of hypogonadism between the two groups. In multiple linear regression analysis, serum free testosterone level significantly decreased with advanced age (a decrease of 1.14 pg/mL per 1-year increase) and a higher body-mass index (BMI) (a decrease of 1.07 pg/mL per 1-kg/m increase), but was not associated with HIV serostatus.
We found that MSM with HIV had a higher prevalence of symptomatic hypogonadism than MSM without HIV in Taiwan, which could be attributed to age difference. Serum free testosterone levels were negatively correlated with age and BMI, but did not show a significant correlation with HIV serostatus.
艾滋病毒（HIV）感染者中男性性腺功能减退症并不少见，估计患病率在 9%至 16%之间。现有的数据仅限于亚洲人群中 HIV 感染者的血清睾酮水平。
我们招募了 2021 年 2 月至 2022 年 11 月期间接受稳定抗逆转录病毒治疗的 HIV 阳性男男性行为者（MSM）和 HIV 阴性 MSM。测量了血清游离睾酮水平、性激素结合球蛋白和其他相关激素。进行多元线性回归分析，评估血清游离睾酮水平与所收集的临床变量之间的关系。
共纳入 447 名 HIV 阳性 MSM 和 124 名 HIV 阴性 MSM。与 HIV 阴性 MSM 相比，HIV 阳性 MSM 的年龄较大（中位数为 41 岁 vs. 29.5 岁），症状性性腺功能减退症的患病率较高（8.3% vs. 1.6%）。在年龄<35 岁的 MSM 中，两组间血清游离睾酮水平和性腺功能减退症的患病率无显著差异。多元线性回归分析显示，血清游离睾酮水平随年龄增长而显著下降（每增加 1 岁下降 1.14 pg/mL），体重指数（BMI）升高（每增加 1 kg/m 下降 1.07 pg/mL），但与 HIV 血清阳性无关。
我们发现，台湾的 HIV 阳性 MSM 比 HIV 阴性 MSM 有更高的症状性性腺功能减退症患病率，这可能归因于年龄差异。血清游离睾酮水平与年龄和 BMI 呈负相关，但与 HIV 血清阳性状态无显著相关性。
